Repeatability of Rest and Hyperemic Myocardial Blood Flow Measurements with 82Rb Dynamic PET

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The repeatability of rest and hyperemic myocardial blood flow (MBF) measurements using 82Rb PET has not been evaluated. The aimof this study was to investigate the short-term repeatability of such measurements. Methods: Fifteen healthy volunteers underwent rest and pharmacologic stress 82Rb PET, repeated 60 min apart. Results: There was no significant difference in repeated rest MBF (0.77 6 0.25 vs. 0.82 6 0.25 mL/min/g, P 5 0.31; mean difference, 6.18% 6 12.22%) or repeated hyperemic MBF (3.35 6 1.37 vs. 3.39 6 1.37 mL/min/g, P 5 0.81; mean difference, 1.17% 6 13.64%). The repeatability coefficients were 0.19 mL/min/g for rest MBF and 0.92 mL/min/g for hyperemia. Conclusion:MBF using 82Rb is highly reproducible using a sameday short-term repeatability protocol. Serial MBF measurements with 82Rb PET should have the ability to quantify the acute effects of therapeutic interventions on MBF.
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