Evidence for the Implication of Endogenous Vasopressin in Cardiovascular Response to Central α-adrenoceptor Stimulation : THE 15th CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
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概要
- 論文の詳細を見る
To determine the role of endogenous vasopressin (AVP) in cardiovascular response to central α-adrenoceptor stimulation, α_1-agonist methoxamine or α _2-agonist clonidine was administered intracerebroventricularly (ICV) to conscious Long-Evans (LE) rats as well as Brattleboro rats with hereditary hypothalamic diabetes insipidus (DI). In LE rats, ICV methoxamine increased blood pressure (BP) and decreased heart rate (HR), while ICV clonidine caused initial hypertension associated with bradycardia followed by prolonged hyportension with tachycardia. In DI rats, however, ICV methoxamine had no detectable effect on BP and HR, whereas CV clonidine produced greater hypotension than in LE rats together with less initial bradycardia. Plasma levels of AVP increased 5-15 fold by methoxamine but did not change by clonidine. The intravenous (IV) but not ICV pretreatment with AVP vascular receptor antagonist d (CH_2)_5 Tyr (Me) AVP significantly attenuated the cardiovascular effects of methoxamine in LE rat, while neither IV nor ICV pretreatment with AVP antagonist modulated the cardiovascular effects of clonidine. These results provide the evidence for the implication of endogenous AVP in the cardiovascular response to central stimulation of α-adrenoceptors.
- 社団法人日本循環器学会の論文
- 1986-11-20
著者
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ABE Keishi
Tohoku University
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Abe Keishi
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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Imai Yutaka
東北大学 臨床薬学
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Yoshida K
Furukawa City Hospital
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Yoshinaga Kaoru
The Second Department Of Internal Medicine Tohoku University School Of Medicine
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IMAI YUTAKA
The Second Department of Internal Medicine, Tohoku University School of Medicine
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HIWATARI MASAO
The Second Department of Internal Medicine, Tohoku University School of Medicine
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Abe Koji
The Department Of Cardiovascular Medicine Graduate School Of Medical Sciences Kumamoto University
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Johnston C
Monash University Department Of Medicine Prince Henry's Hospital
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Johnston Colin
Monash University Department Of Medicine Prince Hospital Melbourne
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Abe Keishi
The Second Department Of Internal Medicine
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Yoshinaga Kaoru.
The 2nd Department Of Internal Medicine Tohoku University School Of Med
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Yoshinaga Keiichiro
Department Of Photobiology Division Of Molecular Cellular Imaging Hokkaido University Graduate Schoo
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