Performance characterization of the Inveon preclinical small-animal PET/SPECT/CT system for multimodality imaging
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概要
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Purpose: We analyzed the performance of the Inveon for an integrated small-animal PET/SPECT/CT system and compared the imaging capabilities of the SPECT and the PET components. Methods: For SPECT, energy resolution, tomographic spatial resolution, and system sensitivity were evaluated with 99mTc solution using a single pinhole collimator. For PET, spatial resolution, absolute sensitivity, scatter fraction, and peak noise equivalent count (NEC) were evaluated. A micro-Derenzo phantom, cylindrical phantom, and National Electrical Manufacturers Association NU-4 image quality phantom were scanned to compare SPECT and PET image capabilities, and SPECT and PET bone imaging were performed on a normal rat in vivo. Results: SPECT spatial resolution was 0.84 mm full width at half maximum (FWHM) at a radius of rotation of 25 mm using the 0.5-mm pinhole aperture collimator, while PET spatial resolution was 1.63 mm FWHM at the center. SPECT system sensitivity at a radius of rotation of 25 mm was 35.3 cps/MBq (4 × 10^[-3]%) using 0.5-mm pinhole aperture, while PET absolute sensitivity was 3.2% for 350-650 keV and 3.432 ns. Accordingly, the volume sensitivity of PET was three orders of magnitude higher than that of SPECT. Conclusions: This integrated PET/SPECT/CT system provided high system performance with excellent spatial resolution for SPECT and sensitivity for PET. Based on tracer availability and system performance, SPECT and PET have complementary roles for multi-modality small-animal imaging.
著者
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Tamaki Nagara
台湾
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Nakata Tomoaki
札幌医科大学 医学部
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Morita Ken
Section Of Urology Kushiro City General Hospital
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Kuge Yuji
Department Of Tracer Kinetics Hokkaido University School Of Medicine
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Kuge Y
Hokkaido Univ. Sapporo Jpn
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Kubo Naoki
Department Of Health Sciences School Of Medicine Hokkaido University
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Zhao Songji
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Nishijima Kenichi
Department Of Molecular Imaging Hokkaido University Graduate School Of Medicine
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Kuge Yuji
Central Institute Of Isotope Science Hokkaido University
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Tamaki Nagara
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Nakata Tomoaki
Department Of Cardiology Sapporo Medical University School Of Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Tamaki Nagara
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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