Dynamic 11C-methionine PET analysis has an additional value for differentiating malignant tumors from granulomas : an experimental study using small animal PET
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概要
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Purpose: We evaluated whether the dynamic profile of 11C-MET may have an additional value in differentiating malignant tumors from granulomas in experimental rat models by small animal PET. Methods: Rhodococcus aurantiacus and allogenic rat C6-glioma cells were inoculated respectively into the right and left calf muscles to generate a rat model bearing both granulomas and tumors (n = 6). Ten days after the inoculations, dynamic 11C-MET PET was performed by small-animal PET up to 120 min after injection of 11C-MET. The next day, after overnight fasting, the rats were injected with 18F-FDG, and dynamic 18F-FDG PET was performed up to 180 min. The time-activity curves, static images, and mean standardized uptake value (SUV) in the lesions were calculated. Results: 11C-MET uptake in the granuloma showed a slow exponential clearance after an initial distribution, while the uptake in the tumor gradually increased with time. The dynamic pattern of 11C-MET uptake in the granuloma was significantly different from that in the tumor (p < 0.001). In the static analysis of 11C-MET, visual assessment and SUV analysis could not differentiate the tumor from the granuloma in all cases, although the mean SUV in the granuloma (1.48 ± 0.09) was significantly lower than that in the tumor (1.72 ± 0.18, p < 0.01). The dynamic patterns, static images, and mean SUVs of 18F-FDG in the granuloma were similar to those in the tumor (p = NS). Conclusions: Dynamic 11C-MET PET has an additional value for differentiating malignant tumors from granulomatous lesions, which deserve further elucidation in clinical settings.
- Springer Berlin / Heidelbergの論文
著者
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Tamaki Nagara
台湾
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Nakata Tomoaki
札幌医科大学 医学部
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Zhao Yan
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Morita Ken
Section Of Urology Kushiro City General Hospital
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Kuge Yuji
Department Of Tracer Kinetics Hokkaido University School Of Medicine
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Kuge Y
Hokkaido Univ. Sapporo Jpn
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Zhao Songji
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Nishijima Kenichi
Department Of Molecular Imaging Hokkaido University Graduate School Of Medicine
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Kuge Yuji
Central Institute Of Isotope Science Hokkaido University
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Tamaki Nagara
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Nakata Tomoaki
Department Of Cardiology Sapporo Medical University School Of Medicine
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Tamaki Nagara
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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