Early Positive Biomarker in Relation to Myocardial Necrosis and Impaired Fatty Acid Metabolism in Patients Presenting With Acute Chest Pain at an Emergency Room
スポンサーリンク
概要
- 論文の詳細を見る
Background Measurement of circulating biomarkers has enabled early diagnosis and risk assessment of acute coronary syndrome. This study sought diagnostic values of the first single-point data of biomarkers obtained soon after patient arrival by comparing with scintigraphically quantified myocardial injury in patients presenting with acute chest pain at an emergency room. Methods and Results Serial blood samples were taken soon after arrival in an emergency department in 74 patients with suspected acute coronary syndrome to quantify blood levels of troponin-T (TnT), heart-type fatty acid-binding protein (H-FABP), myocardial-bound creatine kinase (CK-MB), and myoglobin. Myocardial perfusion and metabolic defects were scintigraphically quantified. The first single-point data had high positive predictive values for detecting the defects (80-100%) but low negative predictive values (15-41%). CK-MB and TnT had higher specificities (73-100%) but significantly lower positive rates (22-27%) than the others (61-68%), resulting in greater sensitivities of H-FABP and myoglobin (75-80%) than those of CK-MB and TnT (29-35%). Among biomarkers, TnT peak concentrations most closely correlated with scintigraphic abnormalities. Conclusion H-FABP can contribute to early detection of myocardial injury and TnT is most likely to correlate with injured myocardial mass. The differential features of biomarkers are complementary in patients with acute chest pain presenting at an emergency room.
- 社団法人日本循環器学会の論文
- 2006-03-20
著者
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Nagahara Daigo
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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Tsuchihashi Kazufumi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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Shimamoto Kazuaki
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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NAKATA Tomoaki
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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HASHIMOTO Akiyoshi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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Hase Mamoru
Department of Traumatology and Critical Care Medicine, Sapporo Medical University School of Medicine
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Sugimoto Ken
東北大学 臨床薬学
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Nakata Tomoaki
Sapporo Medical University School Of Medicine
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Nakata Tomoaki
札幌医科大学 医学部内科学第二
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Nakata Tomoaki
札幌医科大学 医学部
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Nakata Tomoaki
Second Department Of Internal Medicine (cardiology) Sapporo Medical University School Of Medicine
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Tsuchihashi Kazufumi
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Takahashi Toru
Second Department of Surgery, Gunma University Faculty of Medicine
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Kyuma Michifumi
Second department of internal medicine, Sapporo medical university
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Hase Mamoru
Department Of Traumatology And Critical Care Medicine Sapporo Medical University School Of Medicine
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Hase Mamoru
Department Of Traumatology And Critical Care Medicine Sapporo Medical University
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Nagahara Daigo
Second Department Of Internal Medicine (cardiology) Sapporo Medical University School Of Medicine
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HASHIMOTO Akiyoshi
Sapporo Medical University School of Medicine
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Hase Mamoru
Division Of Traumatology And Critical Care Medicine Sapporo Medical University School Of Medicine
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Hase Mamoru
Departments Of Traumatology And Critical Care Medicine Sapporo Medical University
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Nakata Tomoaki
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Kyuma Michifumi
Second Department Of Internal Medicine (cardiology) Sapporo Medical University School Of Medicine
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Hashimoto Akiyoshi
Second Department Of Internal Medicine (cardiology) Sapporo Medical University School Of Medicine
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Tsuchihashi Kazuhumi
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Takahashi Toru
Second Department Of Internal Medicine (cardiology) Sapporo Medical University School Of Medicine
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Shimamoto Kazuaki
Second Department Of Internal Medicine (cardiovascular Medicine) Sapporo Medical University School O
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Hase Mamoru
Department Of Critical Care Medicine Sapporo Medical University School Of Medicine
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Hase Mamoru
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
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Tsuchihasi Kazufumi
The 2nd. Department Of Internal Medicine Sapporo Medical College
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