Long-Term Nitrate Therapy After Acute Myocardial Infarction Does not Improve or Aggravate Prognosis
スポンサーリンク
概要
- 論文の詳細を見る
Background There is conflicting information about whether nitrate treatment aggravates long-term prognosis, so the present retrospective study was designed to determine the effects of long-term nitrate therapy on major adverse events after acute myocardial infarction(AMI) in the coronary interventional era. Methods and Results Using the Japanese Acute Coronary Syndrome Study database, 1,236 consecutive patients who were hospitalized within 48 h of onset of symptoms of AMI from January to December 2003 were evaluated. All-cause mortality, cardiac events and cardiovascular events were lower in patients treated with nitrates than in the untreated controls. However, these crude comparisons included several confounding factors on nitrate prescription. To minimize the effect of selection bias on outcomes, the technique of propensity score matching for clinical characteristics was used and distortion of effective nitrate treatment was excluded as much as possible. The results of propensity score matching showed that nitrate therapy had no impact on all-cause mortality, cardiac events and cardiovascular events at 30, 60 or 90 days, 6 months, 1 year, and 2 years follow-up. Conclusions Long-term nitrate therapy after AMI neither improves nor aggravates prognosis. Prospective randomized clinical trials are warranted to determine the effects of long-term nitrate therapy for secondary prevention of AMI.
- 社団法人日本循環器学会の論文
- 2007-02-20
著者
-
Tei Chuwa
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagos
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Ogawa Hisao
Department of Cardiology, Kumamoto University
-
Tsuchihashi Kazufumi
Second Department of Internal Medicine, Sapporo Medical University School of Medicine
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Sakamoto Tomohiro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
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KIMURA Kazuo
Division of Cardiology, Yokohama City University Medical Center
-
Kojima Sunao
Division of Cardiovascular medicine Kumamoto University Graduate School of Medical Sciences
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Ogata Yasuhiro
Japanese Acute Coronary Syndrome Study (jacss)
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Yamagishi Masakazu
Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science
-
MIYAZAKI Shunichi
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Fujishiroda
-
Hiro Takafumi
Departments Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
-
Ogata Yasuhiro
Japanese Red Cross Kumamoto Hospital
-
Honda Takashi
Division of Cardiology, Cardiovascular Center, Saiseikai Kumamoto Hospital
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ISHIHARA Masaharu
Department of Cardiology, Hiroshima City Hospital
-
Matsuyama Koshi
Clinical Education Center Kumamoto University Hospital
-
Kamide Kei
Department Of Geriatric Medicine Ehime University Graduate School Of Medicine
-
Tomoike Hitonobu
Division Of Preventive Cardiology National Cardiovascular Center
-
Yamagishi Masakazu
Sumitomo Hospital
-
Matsuzawa Y
Department Of Metabolic Medicine Graduate School Of Medicine Osaka University
-
Hao Hiroyuki
Osaka Mishima Emergency And Critical Care Center
-
Kohagura Kentaro
琉球大学 第三内科
-
Yamagishi Masakazu
Division Of Cardiology First Department Of Medicine Osaka University School Of Medicine
-
Hozumi Takeshi
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
-
Sonoda Masahiro
Department of Cardiovascular Medicine, Kumamoto University School of Medicine
-
Hiraoka Hisatoyo
Department Of Surgical Pathology Hyogo College Of Medicine
-
Honda Toshihiro
Departments Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
-
Ishihara Masaharu
Department Of Cardiology Hiroshima City Hospital
-
Tsuchihashi Kazufumi
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
-
Sonoda Masahiro
Japanese Acute Coronary Syndrome Study (jacss)
-
Tei Chuwa
Japanese Acute Coronary Syndrome Study (jacss)
-
Shimoyama Nobuo
Second Department Of Internal Medicine Sapporo Medical University School Of Medicine
-
Kimura Kazuo
Division Of Cardiology Yokohama City University Medical Center
-
Ishihara Masaharu
Japanese Acute Coronary Syndrome Study (jacss)
-
Matsui Kunihiko
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University
-
Hiraoka Hisatoyo
Kagoshima University
-
Ogata Yasuhiro
Cardiovascular Center, Saiseikai Kumamoto Hospital
-
Sugimachi M
National Cerebral And Cardiovascular Center Res. Inst. Osaka Jpn
-
Tei Chuwa
Department Of Cardiology Kagoshima University
-
Satoh Toru
Division Of Cardiology Saiseikai Kumamoto Hospital Cardiovascular Center
-
Miyauchi Katsumi
Clinical Education Center Kumamoto University Hospital
-
Miyazaki Shunichi
Division Of Cardiology Department Of Internal Kinki University School Of Medicine
-
Hosoai Hiroshi
Department Of Surgical Pathology Hyogo College Of Medicine
-
Ogawa Hisao
Department Cardiovascular Medicine Kumamoto University:division Of Intensive Care Unit Kumamoto Univ
-
Hosoda Hiroshi
Osaka Mishima Emergency And Critical Care Center
-
Yamasaki Masao
Department Of Cardiovascular Medicine The Graduate School Of Medicine The University Of Tokyo
-
Matsuyama Kohshi
The First Department Of Internal Medicine Kumamoto University Medical School Kumamoto. Japan
-
Hayashi Tadashi
Department Of Internal Medicine And Cardiology Osaka City University Graduate School Of Medicine
-
Honda Toshihiro
Saiseikai Kumamoto Hospital
-
Honda Takashi
Division Of Cardiology Saiseikai Kumamoto Hospital
-
Sakamoto Tomohiro
Cardiopulmonary Division School Of Medicine Keio University
-
Harada Takehiko
1st. Dept Of Intern. Med. Tokushima Univ. School Of Med.
-
Matsuyama Koshi
Division Of Cardiology Kumamoto University School Of Medicine
-
Sonoda Masahiro
Department Of Cardiology National Hospital Organization Kagoshima Medical Center
-
Yamagishi Masakazu
Division Of Cardiology Department Of Internal Medicine Kanazawa University Graduate School Of Medici
-
Honda Takashi
Cardiovascular Center Saiseikai Kumamoto Hospital
-
Kojima Sunao
Division Of Cardiology Department Of Cardiovascular Dynamics National Cardiovascular Center
-
SAKAMOTO Tomohiro
Department of Cardiovascular Medicine, Graduate School of Medical Sciences Kumamoto University
-
Sakamoto Tomohiro
Department of Cardiology, Saiseikai Kumamoto Hospital, Japan
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