Angiotensin II Receptor Blocker Prevents Increased Arterial Stiffness in Patients With Essential Hypertension

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Background High pulse wave velocity (PWV) is related to cardiovascular risk in essential hypertension (EHT). It is reported that short-term treatment with an angiotensin n receptor blocker (ARE) decreases PWV, as well as blood pressure (BP), and increases the serum adiponectin, known as an adipocytokine, which has an anti-atherosclerotic effect. However, it is not known whether long-term treatment with ARE prevents the increase in PWV independently of the reduction of BP, and whether adiponectin is related to the chronic effect of ARE on PWV. Methods and Results In order to examine the short-term effect of ARE on PWV, 9 subjects with EHT had PWV measured before and after treatment with an ARE for 1 month. The treatment significantly reduced PWV and BP. For evaluation of the long-term effect of ARE therapy, 56 consecutive subjects with EHT who were already taking anti-hypertensive drugs other than an angiotensin-converting enzyme inhibitor had their PWV measured. We divided the EHT subjects into 2 groups: (1) the ARE group (EHT treated with an ARE for at least 6 months) and (2) the control group (EHT treated with anti-hypertensive drugs other than an ARE). Although there was no significant difference between the 2 groups in BP, age or body mass index, the PWV value in the ARE group was significantly lower than that in the control group. Moreover, the serum adiponectin concentration in the ARE group was significantly higher than that in the control group. Conclusions Long-term treatment with ARE inhibits the progression of arterial stiffness independent of BP reduction. One of the mechanisms may be related to the increased serum adiponectin concentration after treatment with an ARE.
社団法人日本循環器学会の論文
2004-11-20

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