Regional partition coefficient of water in patients with cerebrovascular disease and its effect on rCBF assessment
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概要
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Objective: Cerebral blood flow (CBF) estimation with C15O2 PET usually assumes a single tissue compartment model and a fixed brain-blood partition coefficient of water. However, the partition coefficient may change in pathological conditions. The purpose of this study was to investigate the changes of partition coefficient of water in pathological regions and its effect on regional CBF assessment. Methods: Study protocol included 22 patients with occlusive cerebrovascular disease to compare partition coefficients among 3 regions (infarction, non-infarct hypoperfusion, and contralateral) in the pathologic brain (analysis A), and to compare CBF estimated using fixed partition coefficient (CBF fixed) and CBF estimated using floating partition coefficients (CBF float)(analysis B). Results: Partition coefficient in the infarction (0.55 ± 0.07 ml/g) was lower than that in contralateral normal cortex (0.68 ± 0.05 ml/g), whereas non-infarct hypoperfusion did not show a significant change (0.67 ± 0.06 ml/g). As a result, use of a fixed partition coefficient of normal volunteers (0.70 ml/g) resulted in an underestimation in rCBF by 12% in infarction area (P<0.05), while estimation errors were smaller and induced no significant difference in non-infarct hypoperfusion area or in contralateral areas. Conclusions: Partition coefficient is stable except for the infarction, and CBF estimation using a fixed partition coefficient of normal volunteers provides clinically appreciable information in patients with cerebrovascular disease.
- Lippincott Williams & Wilkinsの論文
著者
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Tamaki Nagara
台湾
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Nakata Tomoaki
札幌医科大学 医学部
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Shiga Tohru
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Katoh C
Department Of Health Science Hokkaido University Graduate School Of Medicine
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Kuge Yuji
Department Of Tracer Kinetics Hokkaido University School Of Medicine
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Kuge Y
Hokkaido Univ. Sapporo Jpn
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Kubo Naoki
Department Of Health Sciences School Of Medicine Hokkaido University
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Hirata Kenji
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Hattori Naoya
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Kuge Yuji
Central Institute Of Isotope Science Hokkaido University
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Tamaki Nagara
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Kuroda Satoshi
Hokkaido University Graduate School Of Medicine Department Of Neurosurgery
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Nakata Tomoaki
Department Of Cardiology Sapporo Medical University School Of Medicine
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Shiga Tohru
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Tamaki Nagara
Hokkaido University Graduate School Of Medicine Department Of Nuclear Medicine
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