Evaluating performance of a pixel array semiconductor SPECT system

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Objectives: Small animal imaging has recently been focused on basic nuclear medicine. We havedesigned and built a small animal SPECT imaging system using a semiconductor camera and anewly designed collimator. We assess the performance of this system for small object imaging.Methods: We employed an MGC1500 (Acrorad Co.) camera including a CdTe semiconductor. Thepixel size was 1.4 mm/pixel. We designed and produced a parallel-hole collimator with 20-mm holelength. Our SPECT system consisted of a semiconductor camera with the subject holder set on anelectric rotating stage controlled by a computer. We compared this system with a conventional smallanimal SPECT system comprising a SPECT-2000H scanner with four Anger type cameras andpinhole collimators. The count rate linearity for estimation of the scatter was evaluated for a piechartphantom containing different concentrations of 99mTc. We measured the FWHM of the 99mTcSPECT line source along with scatter. The system volume sensitivity was examined using a floodsource phantom which was 35 mm long with a 32-mm inside diameter. Additionally, an in vivomyocardial perfusion SPECT study was performed with a rat. Results: With regards to energyresolution, the semiconductor camera (5.6%) was superior to the conventional Anger type camera(9.8%). In the count rate linearity evaluation, the regression lines of the SPECT values were y =0.019x + 0.031 (r2 = 0.999) for our system and y = 0.018x + 0.060 (r2 = 0.997) for the conventionalsystem. Thus, the scatter count using the semiconductor camera was less than that using theconventional camera. FWHMs of our system and the conventional system were 2.9 ± 0.1 and 2.0± 0.1 mm, respectively. Moreover, the system volume sensitivity of our system [0.51 kcps/(MBq/ml)/cm] was superior to that of the conventional system [0.44 kcps/(MBq/ml)/cm]. Our systemprovided clear images of the rat myocardium, sufficient for practical use in small animal imaging.Conclusions: Our SPECT system, utilizing a semiconductor camera, permits high quantitativeanalysis by virtue of its low scatter radiation and high sensitivity. Therefore, this system maycontribute to molecular imaging of small animals and basic medical research.
Japanese Society Nuclear Medicineの論文
2005-10-01

Evaluating performance of a pixel array semiconductor SPECT system

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