An ultra-high-energy collimator for small animal imaging in dual-isotope study of 18F and 99mTc
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概要
- 論文の詳細を見る
We have developed a pinhole collimator for small animal imaging using dual-isotopes, such as gamma and positron emitters. A lead cylinder containing a pinhole was placed around the subject (a small animal). The cylinder was equipped with a non-collimator gamma camera, and dual-isotope (99mTc-MIBI and 18F-FDG) SPECT was performed on a Wistar King Aptekman/hok (WKAH) rat. System planar sensitivity and Full-Width at Half-Maximum (FWHM) were measured for each radionuclide. System planar sensitivities for 99mTc and 18F SPECT were 2 and 7 cps/MBq, respectively. FWHMs for 99mTc and 18F SPECT were 2.0±0.5 and 2.7±0.5 mm, respectively. The collimator is relatively light (23 kg), and thus SPECT projection data could be acquired by rotating the gamma camera while the object remained stationary. The pinhole collimator can be used with a conventional rotating gamma camera. The present study demonstrated that it is possible to image organs in vivo in sufficient detail using the newly developed pinhole collimator. Further refinements to the experimental procedure may provide simultaneous high-resolution imaging of small animals using positron and gamma emitters with this collimator.
- Elsevier B.V.の論文
著者
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Nakata Tomoaki
Second Department Of Internal Medicine Sapporo Medicine University
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Tamaki Nagara
Hokkaido University School Of Medicine Department Of Tracer Kinetics And Department Of Nuclear Medic
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Katoh C
Department Of Health Science Hokkaido University Graduate School Of Medicine
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Motomura Nobutoku
Toshiba Medical Systems
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Motomura Nobutoku
Toshiba Medical Engineering Laboratory
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Kubo Naoki
Department Of Health Sciences School Of Medicine Hokkaido University
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Katoh Chietsugu
Department Of Nuclear Medicine Hokkaido University School Of Medicine
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Tamaki Nagara
Hokkaido University Nuclear Medicine
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Zhao Songji
Department Of Nuclear Medicine Hokkaido University Graduate School Of Medicine
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Kinda Akiyoshi
Toshiba Medical Systems
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Kuge Yuji
Central Institute Of Isotope Science Hokkaido University
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