肝細胞癌内科的治療後再発病巣に対するラジオ波凝固壊死療法の治療効果

概要

論文の詳細を見る
The purpose of this study was clarify the therapeutic effect of radiofrequency ablation (RFA) on patients with hepatocellular carcinoma (HCC) having a local recurrent lesion. Methods: We performed RFA on 241 HCC nodules (241 patients) having HCC nodule (less than 3 cm in diameter) between September 1999 and January 2002 under general anesthesia. Among these patients, 65 patients have a local recurrence after the non-surgical treatment, such as PEI, TAE, MCT or RFA. The result of RFA on these patients was compared with others (n=176) who had no history of the prior treatment. Results: During one year after RFA, a local recurrence rate of HCC was 19.5% in the retreatment group and 5.5% in the initial treatment group. Among the 65 HCC nodules in the group, the prevalence of the abnormal serum AFP-L3 level was significantly higher (55.6%) in patients with the second local recurrent nodules after the RFA when it was compared with that in patients without a recurrent nodule. No other factors, such as tumor size, tumor morphology, serum levels of AFP and PIVKA-II, showed a significant correlation with the prevalence of local recurrence after RFA. Conclusion: The effect of RFA was limited on the recurrent HCC nodules resulted in a relatively high prevalence of the second recurrence. In such case, serum AFP-L3 level is useful marker to predict for the second recurrence of HCC.
東京女子医科大学の論文
2003-02-25