ヒト心筋神経支配の免疫組織学的研究 : 心筋梗塞剖検例を用いたS-100β染色の予備的報告

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Astrocyte-derived growth factors are known to promote survival and outgrowth of serotonergic neurons. One of their families, S100 is a calcium-binding protein composed of two subunits, and S-100α and S-100β are expressed selectively by specific cell types. We tried immuno-histochemical S-100β staining to the thin sectioned specimens of formalin-fixed and paraffin-embedded myocardial materials. The materials were obtained from autopsy cases with myocardial infarction (MI) and without MI as control. In control cases, positive S-100β staining element assumed as nerve structure, was found around numbers of cells, including Schwann cells, Purkinje and working myocytes, and negative staining for myocyte, endothelial cell, fibrocyte and fibroblast. In MI cases, the positive S-100β staining element was obtained with almost equal level as control only in fresh MI, but it was reduced in old MI. The evidence suggests that loss of autonomic nerve element was associated with myocyte necrosis due to ischemia.
群馬パース大学の論文