P-10 真菌Penicillium属が生産する新規殺虫活性物質yaequinolone類に関する研究(ポスター発表の部)

概要

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In the course of our screening program for insecticidal antibiotics using Artemia salina (brine shrimp) as a test organism, sixteen structurally related antibiotics named yaequinolones were isolated from the cultured broth of Penicillium sp. FKI-2140, which was isolated from a soil sample collected at Ishigakijima Island, Okinawa Prefecture, Japan. From EtOAc extracts of the 14 day-old culture broth of the strain yaequinolones were purified by CPC and HPLC. The structure was elucidated by various NMR experiments. Yaequinolones possess a methoxyphenyl-quinolinone core with various side chains derived from dimethylallyl or geranyl pyrophosphate. The absolute stereochemistries of the methoxyphenyl-quinolinone moiety are presumed to be 3R4R from the NOE experiments and cotton effects. Insecticidal activity of yaequinolones was studied against A. salina. Compound 9, 11 and 12 showed the most potent growth inhibition with the MIC of 0.19μg/ml, but they showed no cytotoxic activity against Jurkat cell at 100μg/ml.
天然有機化合物討論会の論文
2005-09-15