32 生合成的手段を利用した抗コクシジウム抗生物質Xanthoquinodin類の構造研究(口頭発表の部)

概要

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Xanthoquinodins A, B, C and D produced by Humicola sp. FO-888 were found to exhibit anticoccidial activity in an in vitro assay using Eimeria tenella as a parasite and BHK-21 cells as a host. The deduced structures of xanthoquinodins were confirmed by analysing ^<13>C-labeled xanthoquinodins prepared biosynthetically in ^<13>C-labeled precursor feeding experments on the basis of extensive spectroscopic techniques including ^1H-^1H COSY, ^<13>C-^1H COSY and HMBC. Xanthoquinodins are heterodimers of a xanthone and an anthraquinone moiety, both of which are biosynthesized via octaketide. The stereochemistry of xanthoquinodin B were determined by NMR including NOE experiment. Accordingly, the stereochemistry of xanthoquinodins A, C and D were also deduced by studing the mechanism of nonenzymatic interconversion among xanthoquinodins.
天然有機化合物討論会の論文
1992-09-10