45 Hybrid抗生物質の生産

概要

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Hybrid antibiotics have been obtained by our three kinds of approaches. First approach is hybrid biosynthesis. Hybrid antibiotics. chimeramycins A and B, were constructed by using an enzyme inhibitor cerulenin. Chimeramycins are new hybrid macrolide antibiotics consisting of tylonolide which is the aglycone of tylosin, and forosamine. mycaminose and mycarose all of which are sugars of spiramycin. Second approach is interspecific protoplast fusion among antibiotic-producing organisms. Although interspecific recombinants were obtained at low frequency, the antibiotic productivity was extremely unstable. Third approach is genetic engineering of antibiotic-producing organisms. Hybrid antibiotics, mederrhodins A and B, were produced by a recombinant strain consisting of medermycin-producing Streptomvces sp. AM7161 containing part of the gene clusters for actinorhodin biosynthesis of Streptomvces coelicolor A3(2). Mederrhodin A has a hydroxyl group at the C-6 position of the medermycin molecule and mederrhodin B is dihydromederrhodin A.
天然有機化合物討論会の論文
1985-09-07