Chemistry of Leucomycins. XII. Application of the Modified Polonovski Reaction to Leucomycin-A_3 N-Oxide
スポンサーリンク
概要
- 論文の詳細を見る
An aglycone moiety of leucomycin-A_3 (1), leuconolide-A_3-5,18-hemiacetal (3), was isolated by the application of a modified Polonovski-reaction to leucomycin-A_3 N-oxide (2). Two neutral macrolides, 2'-O-acetyl-3'-N-desdimethylamino-3'-oxo-leucomycin-A_3 (5) and 2'-O-acetyl-3'-N-desmethyl-N-acetyl leucomycin-A_3 (8) in which the mycaminose moiety of 1 was modified, were also isolated from the same reaction. In a similar manner, an aglycone, 9-dehydro-18-dihydro-leuconolide-A_3 (12) was obtained from 9-dehydro-18-dihydro-leucomycin-A_3 (10). While the latter as an isomer of 1,differing with respect to the position of carbonyl group on the lactone ring, has significant antimicrobial activity neither its aglycone 12 nor the aglycone of leucomycin-A_3 show antimicrobial activity.
- 社団法人日本薬学会の論文
- 1976-08-25
著者
-
中川 彰
帝京大理工
-
大村 智
北里研究所生物機能研究所
-
大村 智
Kitasato University and The Kitasato Institute
-
大村 智
北里大薬:北里研
-
TISHLER MAX
Wesleyan University
関連論文
- 98 放線菌の生産する神経突起伸長作用物質ラクタシスチンの生合成研究(ポスター発表の部)
- Chemical Transformation of Tylosin, a 16-Membered Macrolide, and Its Structure-Activity Relationship
- 74 IdiotrophおよびCeruleninを利用するTylosinおよび関連化合物の生合成研究
- Isolation and Characterization of a New 16-Membered Lactone, Protylonolide, from a Mutant of Tylosin-Producing Strain, Streptomyces fradiae KA-427
- Structure of Leucomycin A_1
- 抗HIV活性を有するgp120-CD4結合阻害剤
- 32 生合成的手段を利用した抗コクシジウム抗生物質Xanthoquinodin類の構造研究(口頭発表の部)
- 40 新奇なポリケチド抗生物質フトラマイシン及びオキラクトマイシンの構造と生合成(口頭発表の部)
- 抗生物質--生合成手段を用いる構造決定と新規物質の創製 (動的天然物化学)
- Effects of Phytosterols on Anti-complementary Activity(Pharmacognosy,Chemical)
- 37 新規抗菌抗生物質Aurantininの生合成的手段による構造決定(口頭発表の部)
- 10 放線菌由来の新規大環状ラクタム抗生物質の構造
- 新しい生理活性を有するマクロライド抗生物質
- Herbimycin Bの構造 (生物活性物質)
- 54 Asukamycinの化学構造
- 53 Herbimycin及びElasninの構造^C-nmrを用いる生合成的手段の併用
- Structure of a New Antimicrobial Unsaturated Fatty Acid from Sm. kitasatoensis NU-23-1
- Chemistry of Leucomycins. XII. Application of the Modified Polonovski Reaction to Leucomycin-A_3 N-Oxide
- 57 ^C-NMRによる16員環macrolide抗生物質の生合成研究
- Studies on Cerulenin. VI. Some Spectroscopic Features of Cerulenin
- Revised Structure for an Alkaloid from Streptomyces sp. NA-337
- Alkaloids from Streptomyces sp. NA-337
- 31 ロイコマイシンの化学XI : LeucomycinのAglyconeの単離,mycaminose上の化学的修飾及び16員環macrolide抗生物質の構造と活性
- 59(P-35) 放線菌由来の新規ICAM-1/LFA-1依存性細胞接着阻害物質、Adxanthromycinに関する研究(ポスター発表の部)
- Chemistry of Leucomycins. XI. Chemical Transformation of a Basic Macrolide to a Neutral Macrolide
- Structures and Biological Properties of Kinamycin A, B, C, and D
- Structure of Kinamycin C, and the Structural Relationship among Kinamycin A, B, C, and D
- Chemistry of Leucomycins. VIII. Absolute Configuration of Leucomycin and Isoleucomycin
- The Allylic Rearrangement of the Hydroxyl Group from C-9 to C-13 and the Absolute Configuration at C-9 of Leucomycin A_3
- The Chemistry of Leucomycins. III. Structure and Stereochemistry of Leucomycin A_3
- The Chemistry of Leucomycins. II. Glycosidic Linkages of Mycaminose and Mycarose on Leucomycin A_3
- The Chemistry of Leucomycins. I. Partial Structure of Leucomycin A_3.
- アルギン酸分解酵素生産菌の探索と酵素の精製 : 微生物
- 抗生物質-生合成手段を用いる構造決定と新規物質の創製