Chemical Transformation of Tylosin, a 16-Membered Macrolide, and Its Structure-Activity Relationship

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概要

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• Tylosin is a 16-membered macrolide antibiotic used as veterinary antimicrobial agent. In this paper, we describe the structure of a novel condensation product obtained by acidic hydrolysis and alkaline treatment of tylosin, as well as the isolation of the aglycone part, tylonolide 5,20-hemiacetal, by application of a modified Polonovski reaction to tylosin. Furthermore, we describe syntheses of the intermediates of tylosin biosynthesis and of related compounds, and also the relationship between the structure and antimicrobial activity.

• 社団法人日本薬学会の論文
• 1982-01-25

著者

• 大村 智

  School of Pharmaceutical Sciences, Kitasato University

• 中川 彰

  帝京大理工

• 大村 智

  School Of Pharmaceutical Sciences Kitasato University And The Kitasato Institute

• 大村 智

  北里研究所生物機能研究所

• 松原 肇

  School Of Pharmaceutical Sciences Kitasato University And The Kitasato Institute

• 宮野 勝次

  School of Pharmaceutical Sciences, Kitasato University and The Kitasato Institute

• 中川 彰

  School of Pharmaceutical Sciences, Kitasato University and The Kitasato Institute

• 大村 智

  北里大薬:北里研

• 宮野 勝次

  School Of Pharmaceutical Sciences Kitasato University And The Kitasato Institute

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