Structure of Carzinophilin. II. A New Amino Acid and Its Derivative from Carzinophilin
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概要
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There have been obtained several compounds from the alkaline hydrolysate of carzinophilin. Three of them are 3-methoxy-5-methylnaphthalene-1-carboxylic acid (XIII), its amide (XIV), and 3-hydroxy-5-methylnaphthalene-1-carboxylic acid (XV). The remaining compounds are a new amino acid (XII) and its derivative (XVI). XII is identified with synthetic dl-erythro-4-amino-2,3-dihydroxy-3-methylbutanoic acid and, finally, the absoulte configuration of XII is determined to be the (S)-configuration both at C-2 and C-3 by circular dichroism. Hydrolysis of XVI with 20% hydrochloric acid gives XII and XV. From mass and nuclear magnetic resonance spectra, the structure of XVI is assigned as shown in Chart 4.
- 公益社団法人日本薬学会の論文
- 1971-10-25
著者
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大村 智
School Of Pharmaceutical Sciences Kitasato University And The Kitasato Institute
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秦 藤樹
Kitasato Institute
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根田 八重子
School of Pharmaceutical Sciences, Kitasato University
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秦 藤樹
The Kitasato Institute
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根田 八重子
北里大・薬:北里研
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