Bioconversion and Biosynthesis of 16-Membered Macrolide Antibiotics. XXII. Biosynthesis of Tylosin after Protylonolide Formation

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概要

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• In order to clarify the later stages of tylosin biosynthesis, the biotransformation of tylosin-related compounds to tylosin was examined in a tylosin-producing strain, Streptomyces fradiae KA-427,with the aid of cerulenin, which is an inhibitor of fatty acid and polyketide biosynthesis. Protylonolide (9), 5-O-mycaminosylprotylonolide (11), deepoxycirramycin A_1 (12), 20-deoxy-5-O-mycaminosylrelonolide (13), 5-O-mycaminosyltylonolide (3) and demycarosyltylosin (2) were bioconverted to tylosin. However, 23-hydroxyprotylonolide (10), 20-deoxydemycarosylrelomycin (14) and 20-deoxy-23-O-mycinosylrelonolide (16) were bioconverted not to tylosin, but to 20-deoxyrelomycin (15). Thus, the biosynthetic pathway via compounds 11 and 3 is proposed.

• 社団法人日本薬学会の論文
• 1982-01-25

著者

• 大村 智

  School of Pharmaceutical Sciences, Kitasato University

• 大村 智

  School Of Pharmaceutical Sciences Kitasato University And The Kitasato Institute

• 大村 智

  The Kitasato Institute

• 松原 肇

  School Of Pharmaceutical Sciences Kitasato University And The Kitasato Institute

• 定金 典明

  School of Pharmaceutical Sciences, Kitasato University and The Kitasato Institute

• 定金 典明

  北里大薬

• 定金 典明

  School Of Pharmaceutical Sciences Kitasato University And The Kitasato Institute

関連論文

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• Bioconversion and Biosynthesis of 16-Membered Macrolide Antibiotics. XXII. Biosynthesis of Tylosin after Protylonolide Formation
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