50 センダン(Melia azedarach linn)の摂食阻害活性リモノイド(口頭発表の部)

概要

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In the course of our bioactive limonoid research in Meliaceae plants, many antifeedant limonoids were isolated from the stem and root bark of Okinawan and Chinese Melia azedarach L., respectively. These compounds were very sensitive to traces of acid and composed on attempted CC purification on silica. It was, therefore, necessary to use flash chromatographic and HPLC separation techniques. The isolated liomoids are classified into three groups, one of which is degraded limonoid lactone derivatives. These are 6α-acet-oxyfraxinellone (1), a new compound, and known fraxinellonone. The secondary is azadirachtin-type C-seco limonoids, which are new compounds of 1-cinnamoyl-3-acetyl-11-methoxymeliacarpinin (2) and 3-tigloyl-11-methoxymeliacarpinin (4). The third is intact apoeuphol limonoids with a 14,15-epoxide and a 19/29 lactol bridge, which are also divided into two groups according to their substitution pattern on the A-ring. Azedarachins A (5), B (6) and C (7) are derivatives of 29-deacetylsendanin (3), which was also isolated as a 5:3 mixture of epimers with respect to C-29. On the other hand, three new trichilins, trichilin H (8), 12-acetyl- (9) and 1,12-diacetyltrichilin B (10), were isolated along with trichilins B and D, and meliatoxin A_2.
天然有機化合物討論会の論文
1993-09-10