Drug Binding and Releasing Characteristics of DNA/Lipid/PLGA Film
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated the blended compound of DNA/lipid complexes and PLGA (poly(D, L-lactide-co-glycolide)) as a carrier material for drug delivery system (DDS). Transparent, self-standing DNA/lipid/PLGA films were prepared by casting from an organic solvent such as DMSO/chloroform. Daunorubicin hydrochloride (DH) could intercalate and groove bind into DNA in the films, whereby the amount of DH bound to the films was controlled by the latter's immersion period in DH aqueous solution. DH was released from DH films after immersion in PBS solution, whereby release rate was dependent on the chemical structure of lipids. Released DH caused reduction of cell viability during the cell culture of L929 mouse fibroblasts. These results suggested that DNA/lipid/PLGA film was a promising useful material for DDS.
- 日本歯科理工学会の論文
著者
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HAYAKAWA Tohru
Department of Dental Biomaterial, Nihon University School of Dentistry at Matsudo
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Taniguchi Kunihisa
Department Of Morphological Biology Pathology Section Fukuoka Dental College
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Inoue Yusuke
Fukuoka College Of Health Sciences
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FUKUSHIMA Tadao
Department of Dental Engineering, Bioengineering section, Fukuoka Dental College
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OHNO Jun
Department of Morphological Biology, Pathology section, Fukuoka Dental College
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KAWAGUCHI Minoru
Department of Dental Engineering, Bioengineering section, Fukuoka Dental College
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Hayakawa Tohru
日本大学松戸歯学部 歯科生体材料学
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TAKEDA Shoji
Department of Biomaterials, Osaka Dental University
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Hayakawa Tohru
Department Of Appilied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Fukushima Tadao
Department Of Dental Engineering Bioengineering Section Fukuoka Dental College
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Fukushima Tadao
Associate Professor Department Of Dental Engineering Biomaterials Section Fukuoka Dental College
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Ohno Jun
Department Of Morphological Biology Pathology Section Fukuoka Dental College
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Takeda Shoji
Department Of Biomaterials Osaka Dental University
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Fukushima Tadao
Department Of Dental Engineering Fukuoka Dental College
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Kawaguchi Minoru
Department Of Dental Engineering Bioengineering Section Fukuoka Dental College
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Taniguchi Kunihisa
Section Of Pathology Department Of Morphological Biology Division Of Pathology Department Of Morphol
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Taniguchi Kunihisa
Department Of Morphological Biology Fukuoka Dental College
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Taniguchi Kunihisa
Department Of Biological Morphology Fukuoka Dental College
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