Pre-intercalated DNA/Lipid/PLGA Film as a Drug Carrier
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概要
- 論文の詳細を見る
Complexes of daunorubicin hydrochloride (DH)-intercalated DNA and artificial lipids were synthesized. These DH-pre-intercalated DNA/lipid complexes were blended with PLGA (poly (D, L-lactide-co-glycolide)) to prepare DH-releasable films as a carrier material for a drug delivery system (DDS). The films could release DH in PBS solution. The amount of DH released was dependent on the chemical structure of the lipid and initial concentration of DH in the pre-intercalated DNA. Pre-intercalation slowed the release of DH better than post-intercalation. The DH released caused a reduction in cell viability during the culture of L-929 mouse fibroblasts. DH-pre-intercalated DNA/lipid/PLGA films have potential for the controlled-release of DH.
- 日本再生歯科医学会の論文
- 2008-12-30
著者
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HAYAKAWA Tohru
Department of Dental Biomaterial, Nihon University School of Dentistry at Matsudo
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Inoue Yusuke
Fukuoka College Of Health Sciences
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FUKUSHIMA Tadao
Department of Dental Engineering, Bioengineering section, Fukuoka Dental College
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OHNO Jun
Department of Morphological Biology, Pathology section, Fukuoka Dental College
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KAWAGUCHI Minoru
Department of Dental Engineering, Bioengineering section, Fukuoka Dental College
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Hayakawa Tohru
日本大学松戸歯学部 歯科生体材料学
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Hayakawa Tohru
Department Of Appilied Biology Faculty Of Textile Science Kyoto Institute Of Technology
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Fukushima Tadao
Department Of Dental Engineering Bioengineering Section Fukuoka Dental College
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Fukushima Tadao
Associate Professor Department Of Dental Engineering Biomaterials Section Fukuoka Dental College
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Ohno Jun
Department Of Morphological Biology Pathology Section Fukuoka Dental College
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Fukushima Tadao
Department Of Dental Engineering Fukuoka Dental College
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Kawaguchi Minoru
Department Of Dental Engineering Bioengineering Section Fukuoka Dental College
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