Formation of Fluorescent Products in the Reaction of Adenine and Other Bases with Secondary Oxidation Products of Methyl Linoleate Hydroperoxides(Food & Nutrition)
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概要
- 論文の詳細を見る
The reaction of methyl linoleate hydroperoxides with DNA, nucleosides and DNA bases was investigated by determining the fluorescence formation in the presence of ascorbic acid and Fe^<2+>. Methyl linoleate hydroperoxides produced significant fluorescence only with adenosine and with DNA, but not with the other nucleosides tested. Adenine also produced similar fluorescence, suggesting that the amino group at the 6-position reacted preferentially with the lipid oxidation products to produce fluorescence. The pH level did not have any distinct effect on either the intensity or spectrum of fluorescence in the range of 4.0〜9.0. Among the degradation products of methyl linoleate hydroperoxides, 2-octenal and 2,4-decadienal produced fluorescence with adenine even in the absence of FeSO_4 and ascorbic acid. However, none of these carbonyl compounds produced significant fluorescence in the reaction with DNA, FeSO_4 and ascorbic acid. Potassium iodide, hydroquinone, alpha-tocopherol and BHA reduced the amount of fluorescence. These results suggest that the adenine moiety in DNA reacts with the secondary decomposition products of methyl linoleate hydroperoxides after strand-breaking by radical species derived from methyl linoleate hydroperoxides.
- 社団法人日本農芸化学会の論文
- 1989-06-23
著者
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Hasegawa Kiyoshi
Department of Obstetrics and Gynecology, Matsue Red Cross Hospital
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FUJIMOTO Kenshiro
Department of Food and Nutrition, Koriyama Women's University
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Fujimoto Kenshiro
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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Fujimoto Kenshiro
Department Of Food Chemistry Faculty Of Agriculture Tohoku University
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Kaneda Takashi
Koriyama Women's College
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NEFF William
Northern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture
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FRANKEL Edwin
Northern Regional Research Center, Agricultural Research Service, U.S. Department of Agriculture
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Hasegawa Kiyoshi
Department Of Applied Chemistry Faculty Of Engineering Toyama University
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Neff William
Northern Regional Research Center Agricultural Research Service U.s. Department Of Agriculture
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Frankel Edwin
Northern Regional Research Center Agricultural Research Service U.s. Department Of Agriculture
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Hasegawa K
Department Of Food Chemistry Faculty Of Agriculture Tohoku University
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FUJIMOTO Kenshiro
Department of Applied Biochemistry, Faculty of Agriculture, Tohoku University
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