Dietary Supplementation of Catechins and α-Tocopherol Accelerates the Healing of Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis in Rats

概要

論文の詳細を見る
The effects of dietary catechins and α-tocopherol on inflammatory bowel disease in rats were examined. Male 9-week-old rats were intracolonically administrated trinitrobenzene sulfonic acid (TNBS) and fed the experimental diets containing 0.05% catechin and 0.025% α-tocopherol for 1 week, then dissected. The extent of colitis-induced TNBS was assessed macroscopically. The supplementation of catechins and α-tocopherol significantly decreased colonic damage compared with the group fed the basal diet (the disease control). In particular, catechin feeding completely inhibited the development of colon adhesions. Colonic myeloperoxidase (MPO) activity, which is a marker of neutrophil infiltration into the colonic mucosa, was lower in the groups that had been given catechins and α-tocopherol. The levels of thiobarbituric acid reactive substances in colon was highest in the disease control group; however, the differences among the groups were not significant. Plasma alkaline phosphatase activity was maintained at normal levels in the rats supplemented with catechins and α-tocopherol. These results suggest that catechins and α-tocopherol have anti-inflammatory effects on TNBS-induced rat colitis.
財団法人学会誌刊行センターの論文