Aerosol Infection Test for Evaluation of Pertussis Vaccine(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis Vaccines)
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概要
- 論文の詳細を見る
Evaluation of acellular pertussis vaccine and components of B. pertussis was performed by the use of an in vivo assay system consisting of the mouse aerosol challenge test and the antibody responses in mice. Acellular pertussis vaccine (ACP), pertussis toxin (PT), filamentous hemagglutinin (FHA), fimbriae or whole cell vaccine (WPV) were challenged intrapulmonarily with B. pertussis. The number of colonies of B. pertussis in the lungs of the mice were counted. 1. Does response relationships were observed between the dose of the vaccines, APV or WPV, and B. pertussis colony counts in the lungs of mice injected with one of the vaccines or immunogens. Higher doses of the vaccines or immunogens resulted in reduced numbers of colonies of B. pertussis in the lungs of mice. 2. When the amounts of total protein nitrogen were in the same range, APV and a mixture of PT and FHA showed higher protective efficacy than PT or FHA alone. 3. Rises in antibody tilers were observed in mice injected with APV, WPV, PT or FHA.
- 東海大学の論文
- 1988-09-22
著者
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Kimura M
Department Of Physiology St. Marianna University School Of Medicine
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KUNO-SAKAI Harumi
Department of Pediatrics, School of Medicine, Totaki University
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KIMURA Mikio
Department of Pediatrics, School of Medicine, Totaki University
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SYUKUDA Yukio
Takeda Chemical Industries
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WATANABE Hideo
Department of Pediatric Dentistry, School of Dentistry, Aichi-Gakuin University
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Mikio Kimura
Department Of Pediatrics School Of Medicine Tokai University
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Kimura Mikio
Department Of Infectious Diseases And Applied Immunology Institute Of Medical Science The University
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Fujii Shigeo
Department Of Biological Products Hikari Plant Takeda Chemical Industries
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Kuno‐sakai H
Department Of Community Health School Of Medicine Tokai University
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SYUKUDA Yukio
Department of Biological Products, Hikari Plant, Takeda Chemical Industries
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SUEHARA Akihiro
Department of Biological Products, Hikari Plant, Takeda Chemical Industries
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Kuno-sakai Harumi
Department Of Pediatrics Medicine School Of Medicine Tokai University
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Suehara Akihiro
Department Of Biological Products Hikari Plant Takeda Chemical Industries
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Kimura Mikio
Department Of Infectious Diseases & Applied Immunology Institute Of Medical Science University O
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Watanabe Hideo
Department Of Electronic Engineering Faculty Of Engineering Tohoku University
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Watanabe Hideo
Department Of Biological Products Hikari Plant Takeda Chemical Industries
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Kuno-Sakai Harumi
Department of Community Health, School of Medicine, Tokai University
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Kimura Mikio
Department of Chemistry, Faculty of Science and Engineering, Saga University
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