Characterization and Clinical Study on the Acellular Pertussis Vaccine Produced by a Combination of Column Purified Pertussis Toxin and Filamentous Hemagglutinin(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis
スポンサーリンク
概要
- 論文の詳細を見る
Bordetella Pertussis Tohama phase I was cultured in a 300-liter fermentor using a medium containing 0.1% heptakis (2,5-0-dimethyl) beta-cyclodextrin (MeCD). Pertussis toxin (PT) and filamentous hamagglutinin (FHA) were purified using affinity and ion exchange gel column chromatographies. Endotoxin contents of these antigens (10μgPN/ml) were less than 10 ngLPS/ml. PT and FHA were independently treated with formalin in the presence of amino acid and were mixed at a protein concentration ratio of 1:4, the same ratio of our commercialized acellular pertussis vaccine. PDT vaccine containing 2μgPN of PT and 8μgPN of FHA per milliliter was prepared. This PDT vaccine satisfied all the items of the Japanese Minimum Requirements including potency and toxicity tests. Even after this vaccine was incubated for 4 weeks at 37℃, no deaths of the inoculated mice were observed after challenge with 4 mg of histamine on the 4th and 12th day of the inoculation. Compared with the conventional vaccine, this new vaccine caused less swelling in the mouse footpad test. A field trial of our two vaccines, one manufactured by the conventional method (lot No.21A) and the other produced by the new method (lot No.KC8702), revealed that children receiving KC8702 showed almost the same anti-PT and anti-FHA antibody levels as those given 21A. Those who received KC8702 suffered from less local side effects such as redness, swelling or induration than those given 21A. Our new method for the production of acellular pertussis vaccine permits us the economical manufacturing of the vaccine with uniform quality in a closed system.
- 東海大学の論文
- 1988-09-22
著者
-
SATO Hiroko
Department of Electronic Science and Engineering, Kyoto University
-
SATO Yuji
Department of Mechanical Sciences and Engineering, Tokyo Institute of Technology
-
Kimura M
Department Of Physiology St. Marianna University School Of Medicine
-
KUNO-SAKAI Harumi
Department of Pediatrics, School of Medicine, Totaki University
-
KIMURA Mikio
Department of Pediatrics, School of Medicine, Totaki University
-
SUZUKI YOJI
Teijin Institute for Biomedical Research
-
IMAIZUMI ATSUSHI
Teijin Institute for Biomedical Research
-
UEDA Koji
Kyushu University
-
Mikio Kimura
Department Of Pediatrics School Of Medicine Tokai University
-
Kimura Mikio
Department Of Infectious Diseases And Applied Immunology Institute Of Medical Science The University
-
Kuno‐sakai H
Department Of Community Health School Of Medicine Tokai University
-
UEDA Koji
Department of Information Systems, Daido University
-
GINNAGA Akihiro
The Chemo-Sero Therapeutic Research Institute
-
MOROKUMA Kazunori
The Chemo-Sero Therapeutic Research Institute
-
AIHARA Katsutoshi
The Chemo-Sero Therapeutic Research Institute
-
SAKOU Mitsuo
The Chemo-Sero Therapeutic Research Institute
-
Imaizumi Atsushi
Teijin Institute For Bio-medical Research Teijin Ltd
-
MOROKUMA Kazunori
Human Vaccine Production Department, The Chemo-Sero-Therapeutic Research Institute
-
Kuno-sakai Harumi
Department Of Pediatrics Medicine School Of Medicine Tokai University
-
Kimura Mikio
Department Of Infectious Diseases & Applied Immunology Institute Of Medical Science University O
-
Ueda Koji
Department Of Information Systems Daido University
-
Morokuma K
Human Vaccine Production Department The Chemo-sero-therapeutic Research Institute
-
Ueda Koji
Department Of Electronics Kyushu University
-
Sato Yuji
Department Of Mechanical Science And Engineering Tokyo Institute Of Technology
-
Sato Hiroko
Department Of Bacteriology National Institute Of Health
-
Sato Yuji
Department Of Bacteriology National Institute Of Health
-
Kuno-Sakai Harumi
Department of Community Health, School of Medicine, Tokai University
-
SATO YUJI
Department of Bacteriology, National Institute of Health
-
Kimura Mikio
Department of Chemistry, Faculty of Science and Engineering, Saga University
関連論文
- Fine adhesion patterning and aligned nuclei orientation of mesenchymal stem cell on narrow line-width of silicone rubber implanted by carbon negative ions (第50回真空に関する連合講演会プロシーディングス)
- PJ-118 Runx2 Represses TGF β/Smad-mediated Connective Tissue Growth Factor Gene Expression in Vascular Smooth Muscle Cells(PJ020,Atherosclerosis, Basic 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- PJ-118 Runx2 Represses TGF β/Smad-mediated Connective Tissue Growth Factor Gene Expression in Vascular Smooth Muscle Cells(PJ020,Atherosclerosis, Basic 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- PJ-228 Osteogenic Transcription Factor Runx2 represses Connective Tissue Growth Factor Gene Expression and TGFbeta Signaling in Vascular Smooth Muscle Cells(Atherosclerosis, basic(06)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the
- PE-231 FGF-2 Changes Vascular Smooth Muscle Cell Fate and Induce Osteoblastic Marker Gene Expression via cbfa1.(Vascular Smooth Muscle 1 (H) : PE40)(Poster Session (English))
- PE-043 Klotho transgenic rats show a decrease in oxidative stress and result in restoration in endothelial function(Endothelium/NO 1 (H) : PE8)(Poster Session (English))
- FRS-157 Klotho-defecient mice show endothelial dysfunction and salt-sensitive hypertension(Hypertension (H) : FRS19)(Featured Research Session (English))
- Laser original: Power analysis of a cw solar-pumped laser for magnesium energy cycle (「太陽光励起レーザーとその応用」特集号)
- Production of Endothelin-1 and Big Endothelin-1 by Human Cardiac Myxoma Cells : Implications for the Origin of Myxomas
- PJ-118 Runx2 Represses TGF β/Smad-mediated Connective Tissue Growth Factor Gene Expression in Vascular Smooth Muscle Cells(PJ020,Atherosclerosis, Basic 1 (IHD),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Societ
- Effects of Spaceflight on Enzyme Activities and Ultrastructure of Fast-Type Skeletal Muscles of Rats
- A-band Movement and Junctional Gap Dissociation during Caffeine-induced Contracture of Skeletal Muscle Fibers
- THE EFFECT OF TAURINE LOADING ON THE RESPONSIVENESS OF PLASMA EPINEPHRINE TO THE INFUSION OF GLUCAGON IN YOUNG PATIENTS WITH BORDERLINE HYPERTENSION : Hypertension (II) : FREE COMMUNICATIONS (II) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE
- Salt-Sensitivity in Borderline Hypertension : THE 13TH CONFERENCE ON THE PATHOGENESIS OF HYPERTENSION
- ROLE OF THE SYMPATHETIC NERVOUS SYSTEM IN THE ANTIHYPERTENSIVE EFFECT OF TAURINE IN DOCA-SALT HYPERTENSIVE RATS : Hypertension(II) : II : 48 Annual Scientific Meeting, Japanese Circulation Society
- Role of Sympathetic Nerve Activity and Natriuresis in the Antihypertensive Actions of Potassium in NaCl Hypertension : The 12th Conference on the Pathogenesis of Hypertension
- Identification of the four species of human malaria parasites by nested PCR that targets variant sequences in the small subunit rRNA gene
- Single Locus Analysis of Allelic Variation in the Plasmodium falciparum MSP1 Gene of Field Isolates(Abstracts from the Malaria Workshop)
- Japanese Clinical Trials with Takeda Acellular Pertussis Vaccine(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis Vaccines)
- EFFECT OF HEPTAKIS (2,6-O-DIMETHYL) BETA-CYCLODEXTRIN ON CELL GROWTH AND PRODUCTION OF PERTUSSIS TOXIN OF BORDETELLA PERTUSSIS PHASE I
- Aggressive Lennert's lymphoma : Report of three cases in comparison to non-aggressive Lennert's lymphoma
- Candida albicans induced interleukin 8 production by human keratinocytes
- A Trial of Alloreactive T-cell Depletion Using Biotinylated Galactose Oxidase for the Prevention of Acute Graft-versus-Host Diseases
- Laser original: Laser induced magnesium production using silicon as a reducing agents towards sustainable energy cycle (「太陽光励起レーザーとその応用」特集号)
- Severe acute hepatitis A associated with acute pure red cell aplasia
- Immunological evaluation of peptide vaccination for patients with gastric cancer based on pre-existing cellular response to peptide
- 4 Vascular Calcification : Pathogenesis and Potential Treatment(AHA-JCS Joint Symposium (AHA-JCS Joint Symposium) (IHD) Vulnerable Plaques : Pathogenesis and Noninvasive Approaches to Detection,Special Program,The 72nd Annual Scientific Meeting of the Jap
- PJ-716 Fibroblast Growth Factor 2 Induces Osteoblastic Phenotype in Vascular Smooth Muscle Cells(Vascular smooth muscle-2, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- PJ-710 Notch Signaling Accelerates Vascular Smooth Muscle Differentiation by Inducing Myocardin Gene Expression and by Enhancing the Transactivating Function of Myocardin(Vascular smooth muscle-2, The 71st Annual Scientific Meeting of the Japanese Circula
- OJ-197 HERP1 and HERP2, target genes of Notch, were induced during dedifferentiation of vascular smooth muscle cells(Atherosclerosis, Basic 2 (IHD) : OJ22)(Oral Presentation (Japanese))
- Low Temperature Hetero-Epitaxy of Ferromagnetic Silicide on Ge Substrates for Spin-Transistor Application
- OJ-516 Generation of Hydrogen Peroxide and Activation of c-Src Are Required for TGF-β 1 -Induced Gene Expression : a Novel Mechanism of TGF-β 1 Signaling(Vascular Smooth Muscle 2 (H) : OJ63)(Oral Presentation (Japanese))
- Trial of Isolation of a Virus from Sera of Patients with Kawasaki Disease
- Effect of C^-implantation on Nerve-Cell Attachment to Polystyrene Films
- Polyclonal Increases of Serum Immunoglobulins and Increase of Immunoglobulin-Bearing Peripheral Blood Lymphocytes in Children with Kawasaki Disease
- Efficacy of Nyoshinsan/TJ-67, a traditional herbal medicine, for menopausal symptoms following surgery and adjuvant chemotherapy for premenopausal breast cancer
- Beneficial effect of complementary alternative medicine on lymphedema with rheumatoid arthritis
- FRS-082 Cbfa1 Represses Vascular Smooth Muscle Cells Differentiation by Disrupting the SRF-myocardin Complex(Molecular Biology in Cardiovascular Diseases (basic), The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- OJ-249 Cbfa1, an Osteoblast-specific Transcription Factor, Represses SRF-mediated Smooth Muscle Cell Gene Transcription in Mesenchymal Stem Cells(Vascular smooth muscles-1 (H) OJ42,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meetin
- OJ-248 Jagged1-selective Activation of Notch Signaling Induces Vascular Smooth Muscle Cell Differentiation through RBP-Jk-dependent Mechanism(Vascular smooth muscles-1 (H) OJ42,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of
- FGF-2 Induces Osteoblastic Marker Gene Expression through an Increase in DNA Binding Activity of cbfa-1 in Vascular Smooth Muscle Cells(Atherosclerosis, Basic 3 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- HERP1, a Target Gene of Notch, Maintains Undifferentiated State of Vascular Smooth Muscle Cells by Competing SRF Co-activator, Myocardin(Atherosclerosis, Basic 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)
- Comparative Study of the Asparagine-Linked Sugar Chains of Human Lipocalin-Type Prostaglandin D Synthase Purified from Urine and Amniotic Fluid, and Recombinantly Expressed in Chinese Hamster Ovary Cells
- Bone Marrow Transplantation in Children
- PE-344 Mitochondria! Reactive Oxygen Species and c-Src Play a Critical Role in Hypoxic Response in Vascular Smooth Muscle Cells(Molecular Biology, Vascular 3 (H) : PE59)(Poster Session (English))
- Allogeneic Bone Marrow Transplantation in Children : Tokai Experience 1982 to 1984
- Interferon-β Inhibits Liver Metastases from Murine Colon 26 Carcinoma and its Highly Metastatic Variant
- Usefulness of a New DNA Diagnostic Method for Malaria; Microtiter Plate-Hybridization(Abstracts from the Malaria Workshop)
- Effect of Timing of Meal Intake after Squat Exercise Training on Bone Formation in the Rat Hindlimb
- CASES OF OVALE MALARIA AND MALARIAE MALARIA SUCCESSFULLY TREATED WITH MEFLOQUINE
- Detection of Road Surface States from Tire Noise Using Neural Network Analysis
- Detection of Road Surface Conditions Using Tire Noise from Vehicles
- Effect of Meal Timing after Resistance Exercise on Hindlimb Muscle Mass and Fat Accumulation in Trained Rats
- Relative frequencies of polymorphisms of variation in Block 2 repeats and 5' recombinant types of Plasmodium falciparum msp 1 alleles
- A PCR Method for Molecular Epidemiology of Plasmodium falciparum Msp-1
- Adverse events associated with MMR vaccines in Japan
- Immunogenicity and reactogenicity of the component acellular pertussis vaccine produced by a combination of column purified pertussis toxin and filamentous haemagglutinin
- Aerosol Infection Test for Evaluation of Pertussis Vaccine(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis Vaccines)
- Characterization and Clinical Study on the Acellular Pertussis Vaccine Produced by a Combination of Column Purified Pertussis Toxin and Filamentous Hemagglutinin(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis
- Pertussis Vaccine Acceptance Rates and Incidence of Pertussis in Forty Seven Districts (Prefectures) in Japan Since 1977(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis Vaccines)
- Evaluation of Mumps Antibodies after Measles-Mumps-Rubella (MMR) Vaccines
- Anterior Mediastinal Mass due to Malignant Lymphoma of Convoluted Lymphocytes
- Activated caspase expression and apoptosis increase in keloids : cytochrome c release and caspase-9 activation during the apoptosis of keloid fibroblast lines
- Removal of Digitalis from Human Plasma using Immunoadsorbents
- Sound Pressure Fields Focused Using Biconcave Acoustic Lens for Normal Incidence
- Correlation of the Modified Scratch Test with the Radioallergosorbent Test (RAST) in Atopic Children
- Effects and Side Effects of a New Trivalent Combined Measles-Mumps-Rubella (MMR) Vaccine
- Hard-copy versus Soft-copy Image Reading for Detection of Ureteral Stones on Abdominal Radiography
- CIN85 Is Localized at Synapses and Forms a Complex with S-SCAM via Dendrin
- Improvement in Symptoms and QuantiFERON TB-2G Test Results after Isoniazid Administration in a Patient with Normal Routine Tests Results
- A Rapid Solid Phase Radioimmunoassay of Virus Particles
- Protective effect of nasal immunization of influenza virus hemagglutinin with recombinant cholera toxin B subunit as a mucosal adjuvant in mice
- Clinical and Bacteriological Profiles of Patients with Typhoid Fever Treated during 1975-1998 in the Tokyo Metropolitan Komagome Hospital
- Simple Microassay of Urinary Protein using a Membrane Filter
- Dissociation of Digoxin-Antibody Complex after Addition of Dextran-Coated Charcoal in the Radioimmunoassay of Digoxin
- Rapid, sensitive and specific diagnosis of Bordetella pertussis using the polymerase chain reaction
- Enzyme Linked Immunosorbent Assay of Rubella Antibody
- Dynamics of Transplacental Transmission of Pertussis Antibodies in Premature and Full Term Infants
- Effects of Recombinant Cholera Toxin B Subunit (rCTB) on Cellular Immune Responses : Enhancement of Delayed-Type Hypersensitivity Following Intranasal Co-Administration of Mycobacterium bovis-BCG with rCTB
- Effects of Recombinant Cholera Toxin B Subunit on IL-1β Production by Macrophages In Vitro
- Classification System for the Completely Dentate, Partial and Complete Edentulism
- Evaluation of polymerization-dependent changes in color and translucency of resin composites using two formulae
- A rapid, simple and sensitive flow cytometric system for detection of Plasmodium falciparum
- Magnetic and Electric Properties of Iron-Silicon Alloys
- Reports on Cases of Neurological Illnesses Occurring after Administration of Acellular Pertussis Vaccines in Japan(B. Vaccine Schedules: Their Pelationship to Current Epidemiology)(II. The Eradication of Pertussis: Current Unsolved Epidemiologic, Clinical
- Experiences with Acellular Pertussis Vaccine in Japan and Epidemiology of Pertussis
- Epidemiology of Pertussis in Japan(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis Vaccines)
- Effects of Hair Washing on Skin Temperature and Thermal Sensation
- THE EFFECTS OF PARAQUAT ON CULTURED HUMAN EMBRYONIC CELLS
- GROWTH AND FOOD CONSUMPTION IN PLAICE Part II KAREIUS BICOLORATUS (BASILEWSKY)
- GROWTH AND FOOD CONSUMPTION IN PLAICE Part I LIMANDA YOKOHAMAE (GUNTHER)
- A Novel Bite-raising Procedure for Complete Dentures
- The Relationship between Subjective Evaluation and Objective Evaluation on the Examination for the Residual Ridge Height of Edentulous Patients
- Prediction of Mandibular Movement by the Observation of Facial Skin Markers
- Doctor-Patient Communication: A Comparison betweenTelemedicine Consultation and Face-to-Face Consultation
- Further Characterization of Japanese Acellular Pertussis Vaccine Prepared in 1988 by 6 Japanese Manufacturers(I. Current Situation of Acellular Pertussis Vaccines)(Clinical Aspects of Acellular Pertussis Vaccines)
- Type A1 but Not Type A2 Botulinum Toxin Decreases the Grip Strength of the Contralateral Foreleg Through Axonal Transport From the Toxin-Treated Foreleg of Rats
- Epitaxial Growth of Ferromagnetic Silicide Fe3Si on Si(111) Substrate
- Clinical Efficacy of Antivenom and Cepharanthine for the Treatment of Mamushi (Gloydius blomhoffii) Bites in Tertiary Care Centers in Japan
- Association of breast-fed neonatal hyperbilirubinemia with UGT1A1 polymorphisms : 211G>A (G71R) mutation becomes a risk factor under inadequate feeding