A PCR Method for Molecular Epidemiology of Plasmodium falciparum Msp-1

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概要

• 論文の詳細を見る

• Merozoite surface protein-1 (MSP-1) of Plasmodium falciparum is a strong malaria vaccine candidate. However, MSP-1 exhibits extensive antigenic polymorphism, an issue which may compromise the development of effective vaccine based on this molecule. Since polymorphic nature of MSP-1 has not been fully understood in endemic areas of malaria, variation of the MSP-1 gene (Msp-1) must be studied in detail in natural parasite populations. Here, a PCR-based method for determination of P. falciparum Msp-1 haplotype is described, which can detect up to 24 different haplotypes per infected person. The method can be applied to various purposes of molecular epidemiology of not only Msp-1 haplotype but the genetic structure of P. falciparum populations.

• 東海大学の論文
• 1998-08-29

著者

• Kimura M

  Department Of Physiology St. Marianna University School Of Medicine

• Saito-ito Atsuko

  Department Of Medical Zoology Kobe University School Of Medicine

• Kaneko O

  National Inst. For Fusion Sci. Gifu Jpn

• Kaneko Osamu

  Laboratory Of Biophysics And Department Of Medical Zoology Osaka City University Medical School

• KIMURA Masatsugu

  Laboratory of Biophysics, Osaka City University Medical School

• TANABE Kazuyuki

  Laboratory of Biology, Osaka institute of Technology

• Mikio Kimura

  Department Of Pediatrics School Of Medicine Tokai University

• Kawabata Masato

  Kobe University School Of Medicine

• Sakihama N

  Department Of Biology Faculty Of Science Kobe University

• Sakihama Naoko

  Laboratory Of Biology Osaka Institute Of Technology

• Tanabe Kazuyuki

  Laboratory Of Biology Osaka Institute Of Technology

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