Effects of Mefloquine Usage on Genetic Polymorphism of Plasmodium Falciparum in Thai-Myanmarese Border

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概要

• 論文の詳細を見る

• We studied the polymorphism of msp-1, which encodes a major surface protein onthe merozoite, isolated from blood samples from western Thailand in 1999. Our studyarea was a low-transmission area for malaria, where mefloquine has been used as anantimalarial drug since 1994. Forty-nine patients were confirmed to have contractedfalciparum malaria twice within 24 weeks. The number of detected haplotypes in 49patients was 89 at the first diagnosis and 68 at the second diagnosis. The mean numberof haplotypes per patient significantly decreased from 1.82 to 1.39 but the frequencydistributions of msp-1 haplotypes did not change significantly with the use ofmefloquine. Our study strongly suggests that the antigenic diversity of Plasmodium falciparum is retained during mefloquine therapy in low-transmission areas.

• 神戸大学の論文

著者

• Shirakawa T

  Kobe University School Of Medicine

• Shirakawa Toshiro

  Kobe University Graduate School Of Medicine

• SINGHASIVANON Pratap

  Asian Center of International Parasite Control, Faculty of Tropical Medicine, Mahidol University

• LOOAREESUWAN Sornchai

  Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University

• Singhasivanon Pratap

  Asian Center Of International Parasite Control Faculty Of Tropical Medicine Mahidol University

• Singhasivanon Pratap

  Mahidol University

• Kawabata Masato

  Kobe University School Of Medicine

• Sakai T

  Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School

• Matsuo Toshiaki

  Kobe University School of Medicine

• Looareesuwan Sornchai

  Mahidol University

• Looareesuwan S

  Department Of Clinical Tropical Medicine Faculty Of Tropical Medicine Mahidol University

• Looareesuwan Sornchai

  Faculty Of Tropical Medicine Mahidol University Bangkok Thailand

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