Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance
スポンサーリンク
概要
- 論文の詳細を見る
Malaria is a protozoan disease transmitted by the bite of the Anopheles mosquito. Among five species that can infect humans, Plasmodium falciparum is responsible for the most severe human malaria. Resistance of P. falciparum to chloroquine and pyrimethamine/sulfadoxine, conventionally used antimalarial drugs, is already widely distributed in many endemic areas. As a result, artemisinin-based combination therapies have been rapidly and widely adopted as first-line antimalarial treatments since the mid-2000s. Recent population and evolutionary genetic analyses have proven that the geographic origins of parasite lineages resistant to the conventional drugs are considerably limited. Almost all resistance emerged from either Southeast Asia or South America. The Greater Mekong subregion in Southeast Asia is probably the most alarming source of resistance, from which P. falciparum resistant to chloroquine and pyrimethamine/sulfadoxine dispersed to Africa. The emergence of artemisinin resistance has also recently been confirmed in the Greater Mekong. The WHO Global Malaria Programme has recently launched a "Global Plan for Artemisinin Resistance Containment," which aims to prevent the spread of artemisinin resistance while also stopping the emergence of novel resistance. However, an inadequate understanding of a mechanism of artemisinin resistance and the lack of reliable genetic markers to monitor artemisinin resistance make it difficult to survey the spread of resistance. Elucidation of such markers would substantially contribute to the design of an effective policy for the containment of artemisinin resistance.
- National Institute of Infectious Diseasesの論文
著者
-
Mita Toshihiro
Department Of Gastroenterology And Hepatology Jikei Medical University School Of Medicine
-
Tanabe Kazuyuki
Laboratory Of Biology Osaka Institute Of Technology
-
Mita Toshihiro
Department of Molecular and Cellular Parasitology, Juntendo University School of Medicine
関連論文
- Glucose-6-Phosphate Dehydrogenase (G6PD) Variants in Three Minority Ethnic Groups in Central and Northern Vietnam
- The status of malaria before and after distribution of ITNs from 1999 to 2006 in two districts of Khammouanne Province, Lao P.D.R
- Identification of the four species of human malaria parasites by nested PCR that targets variant sequences in the small subunit rRNA gene
- MALARIA ENDEMIC PATTERNS ON LOMBOK AND SUMBAWA ISLANDS, INDONESIA
- MSP1-reactive T cells in individuals in malaria endemic Solomon area and in non-immune Japanese
- Risk factors for lymph node metastasis of submucosal invasive differentiated type gastric carcinoma : clinical significance of histological heterogeneity
- Glucose - 6 - Phosphate Dehydrogenase (G6PD) variants in East Sepik Province of Papua New Guinea : G6PD Jammu, G6PD Vanua Lava, and a novel variant (G6PD Dagua)
- Relative frequencies of polymorphisms of variation in Block 2 repeats and 5' recombinant types of Plasmodium falciparum msp 1 alleles
- A PCR Method for Molecular Epidemiology of Plasmodium falciparum Msp-1
- A multiplex polymerase chain reaction for a differential diagnosis of Plasmodium falciparum and Plasmodium vivax
- Spread and evolution of Plasmodium falciparum drug resistance
- Cross-reactivity in rapid diagnostic tests between human malaria and zoonotic simian malaria parasite Plasmodium knowlesi infections
- High prevalence of Sulfadoxine/pyrimethamine resistance alleles in Plasmodium falciparum parasites from Bangladesh
- Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance