Effects of 2450 MHz Electromagnetic Fields with a Wide Range of SARs on Methylcholanthrene-induced Transformation in C3H10T1/2 Cells

概要

論文の詳細を見る
This study examined whether 2450MHz continuous wave high frequency electromagnetic fields (HFEMF) could induce cancer-like changes in mouse C3H10T1/2 cells, and whether HFEMF could initiate malignant or synergistic transformation. Transformed foci, Type II and Type III, were independently counted as the experiment endpoint. The cells were exposed to HFEMF alone at a wide range of specific absorption rates (SARs) of 5 to 200W/kg for 2h and/or were treated with a known initiating chemical, methylcholanthrene (MC) (2.5μg/ml). No significant differences were observed in the malignant transformation (Type II+Type III) frequency between the controls and HFEMF with or without 12-O-tetradecanoylphorbol-13-acetate (TPA) (0.5ng/ml), a tumor promoter that could enhance transformation frequency initiated by MC in multistage carcinogenesis. However, the transformation frequency for HFEMF at SAR of more than 100W/kg with MC or MC plus TPA was increased compared with MC alone or MC plus TPA. On the other hand, the corresponding heat groups (heat alone, heat+MC, and heat+MC+TPA) did not increase transformation compared with each control level in C3H10T1/2 cells. This result suggests that 2450MHz HFEMF could not contribute to the initiation stage of tumor formation, but it may contribute to the promotion stage at the extremely high SAR (≥100W/kg).
日本放射線影響学会の論文
2005-09-30