Increased Norepinephrine by Medium-Chain Triglyceride Attributable to Lipolysis in White and Brown Adipose Tissue of C57BL/6J Mice
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概要
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A further investigation of the lipolysis induced by medium-chain triglyceride (MCT) was conducted on C57BL/6J mice fed with a diet containing 2% MCT or 2% long-chain triglyceride (LCT). Blood norepinephrine, body fat and blood lipid variables, and the protein or mRNA expression of the genes relevant to lipolysis were measured and analyzed in the white and brown adipose tissue (WAT, BAT). Decreased body fat and improved blood lipid profiles attributable to MCT were confirmed. A higher level of blood norepinephrine was observed with the MCT diet. The adipose triglyceride lipase (ATGL) activity and its mRNA expression, the expression of protein and mRNA of the beta 3 adrenergic receptor (β3-AR) in both WAT and BAT, and the hormone-sensitive lipase (HSL) activity and its mRNA expression in BAT were significantly increased in the mice with MCT feeding. The lipolysis induced by MCT might be partially mediated by increasing norepinephrine, thereafter signaling the up-regulation of β3-AR, ATGL, and HSL in WAT and BAT.
- 2012-06-23
著者
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Wu Jian
国立健康･栄養研究所 食品機能研究部
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LIU Yinghua
Department of Nutrition, Chinese PLA General Hospital
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Zhang Yong
Dep. Of Nutrition Chinese Pla General Hospital
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Xue Changyong
Department Of Nutrition Chinese Pla General Hospital
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XU Qing
Department of Nutrition, Chinese PLA General Hospital
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Zhang Yong
Department Of Chemistry & Chemical Engineering Suzhou University
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Wang Jin
Department Of Biological Sience And The Mervin Bovaird Center For Studies In Molecular Biology And B
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Xu Qing
Department Of Nutrition Chinese Pla General Hospital
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Liu Yinghua
Institute Of Hygiene And Environmental Medicine Academy Of Military Medical Sciences
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Yang Xue-yan
Department Of Nutrition Chinese Pla General Hospital
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LIU Ying-hua
Department of Nutrition, Chinese PLA General Hospital
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YU Xiao-ming
Department of Nutrition, Chinese PLA General Hospital
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ZHANG Xin-sheng
Department of Nutrition, Chinese PLA General Hospital
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XUE Chao
Peking University Health Science
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ZHANG Rong-xin
Department of Nutrition, Chinese PLA General Hospital
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XUE Chang-yong
Department of Nutrition, Chinese PLA General Hospital
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Wang Jin
Department Of Nutrition Chinese Pla General Hospital
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Zhang Yong
Department Of Applied Bioresource Science The United Graduate School Of Agricultural Sciences Ehime University
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