Stereoselective Characteristics and Mechanisms of Epidermal Carboxylesterase Metabolism Observed in HaCaT Keratinocytes(Biopharmacy)
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概要
- 論文の詳細を見る
There is increasing evidence that epidermal carboxylesterase may be involved in the stereoselective hydrolysis of prodrugs in percutaneous absorption. The present study was designed to evaluate the stereoselective characteristics and mechanisms of ketoprofen ethyl ester hydrolysis by epidermal carboxylesterase expressed in HaCaT keratinocytes. Ketoprofen ethyl ester was .mainly hydrolyzed to R-ketoprofen by carboxylesterase of human HaCaT keratinocytes. Human carboxylesterase-1 (hCE-1) and human carboxylesterase-2 (hCE-2) were intensively detected in LO2 hepatocytes, hCE-2 was also intensively detected in HaCaT keratinocytes, but hCE-1 was not detected in HaCaT keratinocytes, hCE-2 is thus an abundant carboxylesterase in HaCaT keratinocytes which may be responsible for stereoselective hydrolysis of ketoprofen ethyl ester.
- 公益社団法人日本薬学会の論文
- 2007-03-01
著者
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WANG Jin
Department of Clinical Hematology, Second Hospital of Xi'an Jiaotong University
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Liu Yan-xia
Department Of Pharmacy Changhai Hospital Second Military Medical University
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Wang Jin
Department Of Pharmaceutical Sciences Changhai Hospital Second Military Medical University
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Liu Ji-yong
中華人民共和国
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Liu Ji-yong
Department Of Pharmaceutical Sciences Changhai Hospital Second Military Medical University
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HU Jin-Hong
Department of Pharmacy, Changhai Hospital, Second Military Medical University
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ZHU Quan-Gang
Department of Pharmacy, Changhai Hospital, Second Military Medical University
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Hu Jin-hong
Department Of Pharmaceutical Sciences Changhai Hospital Second Military Medical University
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Zhu Quan-gang
Department Of Pharmaceutical Sciences Changhai Hospital Second Military Medical University
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Wang Jin
Department Of Biotechnology Faculty Of Engineering Nagoya University
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Hu Jin-hong
Changhai Hospital Second Military Medical Univ.
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Liu Ji-yong
Changhai Hospital Second Military Medical Univ.
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LU Song-Wei
Department of Pharmacy, Changhai Hospital, Second Military Medical University
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Lu Song-wei
Department Of Pharmacy Changhai Hospital Second Military Medical University
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Wang Jin
Department Of Biological Sience And The Mervin Bovaird Center For Studies In Molecular Biology And B
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LIU Yan-Xia
Department of Neurology, the First Affiliated Hospital of Xinxiang Medical University
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