Improvement of the Dissolution Rate of Silymarin by Means of Solid Dispersions

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概要

• 論文の詳細を見る

• Solid dispersions of silymarin were prepared by the fusion method with the intention of improving the dissolution properties of silymarin. Polyethylene glycol 6000 (PEG 6000) was used as the inert hydrophilic matrix. The dissolution studies of the solid dispersions were performed in vitro. And the results obtained showed that the dissolution rate of silymarin was considerably improved when formulated in solid dispersions with PEG 6000 as compared to original drug, and the increased dissolution rate might be favorable for further oral absorption.

• 公益社団法人日本薬学会の論文
• 2004-08-01

著者

• Li Feng-qian

  Department Of Pharmaceutical Sciences Changhai Hospital Second Military Medical University

• HU Jin-Hong

  Department of Pharmacy, Changhai Hospital, Second Military Medical University

• Hu Jin-hong

  Department Of Pharmaceutical Sciences Changhai Hospital Second Military Medical University

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