Long-term Exposure to a Magnetic Field (5 mT at 60 Hz) Increases X-ray-induced Mutations
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概要
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Exposure to extremely low frequency magnetic field (ELFMF) at 400 mT has been shown to induce mutations (Mutat. Res., 349: 109-114, 1996; Int. J. Radiat. Biol., 71: 75-79, 1997; and Biochem. Biophys. Res. Commun., 243: 579-584, 1998). However, whether ELFMF at low flux densities (under 1 mT) induces mutations is debatable. We investigated the effect of long-term exposure to 5 mT ELFMF at 60 Hz on mutant frequency. Chinese hamster ovary K1 (CHO-K1) cells were exposed or sham-exposed to 5 mT ELFMF for up to 6 weeks with or without X-irradiation (3 Gy), and the mutant frequency of the hypoxanthine- guanine phosphoribosyl transferase (HPRT) gene was analyzed. Long-term exposure to 5 mT ELFMF did not increase mutations, suggesting a threshold for mutation induction greater than 115 mA/m^2 or a magnetic density of 5 mT. However, enhancement of the X-ray-induced mutation rate was observed after treatment with X-irradiation followed by long-term exposure to 5 mT ELFMF. At little as a 1-week exposure to ELFMF after X-irradiation enhanced the mutation rate. We also found that 400 mT exposure enhanced the mutation rate induced by X-irradiation (Mutat. Res., 349: 109-114, 1996). These results suggest that exposure to more than 5 mT ELFMF may promote X-ray-induced mutations.
- 日本放射線影響学会の論文
著者
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Miyakoshi Junji
Department of Radiation Genetics,Graduate School of Medicine Kyoto University
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Koji Yasuhiro
Department Of Radiation Genetics Graduate School Of Medicine Kyoto University
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Miyakoshi Junji
Department Of Radiation Biology Kyoto College Of Pharmacy
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Takebe Hiraku
Atomic Energy Research Institute Kinki University
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WAKASA TETSUJI
Department of Radiation Genetics, Graduate School of Medicine, Kyoto University
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Wakasa Tetsuji
Department Of Radiation Genetics Graduate School Of Medicine Kyoto University
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