Evaluation of ^<99m>Tc-Labeled Amino Acids as Radiopharmaceuticals. VI. N-Pyridoxylidenehydrazine-N', N'-diacetic Acid

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^<99m>Tc labeled N-pyridoxylidenehydrazine-N', N'-diacetic acid and related hydrazones were evaluated as hepatobiliary imaging agents. Hydrazones used in the study were N-pyridoxylidenehydrazine-N', N'-diacetic acid (PLHzDA), N-(3-hydroxy-4-pyridylmethylene) hydrazine-N', N'-diacetic acid (FHPHzDA), N-(4-pyridylmethylene) hydrazine-N', N'-diacetic acid (INHzDA), and N-pyridoxylidene-N', N'-dimethylhydrazine (PLDMHz). The hydrazones were labeled with ^<99m>Tc by the SnCl_2 method and the ^<99m>Tc labeling was examined by thin-layer chromatography and high-performance liquid chromatography. ^<99m>Tc labeled hydrazones were administered to golden hamsters, and the distribution indicated that clearance occurred through the hepatobiliary system. Scintigraphic studies in rabbits indicated that ^<99m>Tc-labeled PLHzDA and FHPHzDA are useful hepatobiliary radiotracers.
社団法人日本薬学会の論文
1984-06-25