Evaluation of ^<99m>Tc Labeled Amino Acids as Radiopharmaceuticals IV. S-Substituted Cysteines and N-Substituted Iminodiacetic Acids

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Sixteen ^<99m>Tc labeled ligands were evaluated as scintigraphic agents. The ligands studied were cysteine, glutathione, their S-substituted derivatives, lysine. N^ε , N^ε-diacetic acid, glycyglycine-N, N-diacetic acid, glycylglycylglycine-N, N-diacetic acid, taurine-N, N-diacetic acid, hydrazine-N, N-diacetic acid, ethylenediamine-N, N-diacetic acid, and propylene-1 , 3-diamine-N1-, N1-diacetic acid. The ligands were labeled with ^<99m>Tc by the SnCl_2 method with more than 95% yield. The in vivo behavior of the ^<99m>Tc labeled ligands were studied in golden hamsters and dogs. The organ distribution in golden hamsters indicated clearance both by hepatobiliary and renal systems. The pancreas/blood ratios were much lower in the ^<99m>Tc ligands than in ^<75>Se-selenomethionine. Scintigraphic studies in dogs showed that the liver and kidneys were well visualized but the accumulation by the pancreas was not sufficient for clear visualization.
日本放射線影響学会の論文