Enzymatic Formation of 5-Fluorouracil from 1-(Tetrahydro-2-furanyl)-5-fluorouracil (Tegafur) in Human Tumor Tissues
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概要
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1-(Tetrahydro-2-furanyl)-5-fluorouracil (Tegafur) was phosphorolyzed to form 5-fluorouracil (5-FU) by a soluble fraction of human lung cancer. The catalysis was suppressed in the presence of excess thymidine, but not in the presence of 1-(2'-deoxy-β-D-glucopyranosyl) thymine, an inhibitor of uridine phosphorylases. The cleavage of Tegafur to 5-FU was assumed to be catalyzed by a thymidine phosphorylase activity, which is greatly enhanced in the human tumor tissues, and to represent a possible activation mechanism of Tegafur.
- 社団法人日本薬学会の論文
- 1981-05-23
著者
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松島 美一
共立薬大
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河野 彬
Kyushu Cancer Center Research Institute
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松島 美一
Faculty of Pharmaceutical Sciences, Kyushu University 62
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松島 美一
Faculty Of Pharmaceutical Sciences Kyushu University
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原 泰寛
Kyushu Cancer Center Research Institute
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河野 彬
国立九州がんセンター
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