Radioactive Metal Complexes of Ethylenediamine-N, N-diacetic Acid. Biodistribution of Radioactivity in Mice Bearing Tumors

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概要

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• Complexes of ethylenediamine-N, N-diacetic acid (EDDA) with radioactive metal ions and ^3H-labeled EDDA were prepared and the biodistribution of the radioactivity in mice bearing Ehrlich tumor was studied. Radioactive complexes studied were those of ^<51>Cr, ^<57>Co, ^<59>Fe, ^<64>Cu, and ^<67>Ga. μ-Oxo ^<57>Co EDDA was prepared by treatment of ^<57>Co EDDA with hydrogen peroxide. The tumor/blood ratios of radioactivity indicated that ^<57>Co EDDA and μ-oxo ^<57>Co EDDA were concentrated in the tumor tissues, whereas other complexes and ^3H-EDDA were not. The tumor tissues were clearly visualized in scintigrams after the administration of the ^<57>Co complexes to mice.

• 社団法人日本薬学会の論文
• 1984-10-25

著者

• 高田 二郎

  福岡大学薬学部

• 松島 美一

  Kyoritsu College of Pharmacy

• 松島 美一

  共立薬大

• 加留部 善晴

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 加留部 善晴

  福岡大(薬)

• 高田 二郎

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 山本 孫兵衛

  Faculty of Pharmaceutical Sciences, Fukuoka University

• 河野 彬

  Cancer Center Research Institute

• 河野 彬

  国立九州がんセンター

• 山本 孫兵衛

  Faculty Of Pharmaceutical Sciences Fukuoka University

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