^<131>I-6β-Iodomethyl-19-norcholest-5(10)-en-3β-ol(NCL-6-^<131>I)のラット体内分布におよぼす比放射能および利胆剤の効果

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Attempts to improve adrenal imaging with ^<131>I-6β-iodomethyl-19-norcholest-5 (10)-en-3β-ol (NCL-6-^<131>I) were made. Various NCL-6-^<131>Is with higher specific activity than those used clinically were prepared. An increase in specific activity of NCL-6-^<131>I had no significant effect on the rat adrenal uptake, but caused an increase in the liver concentration of radioactivity. Lipid extraction and radiochromatographic analysis showed the presence of unchanged NCL-6-^<131>I in the liver, but in the adrenal the esterified form of NCL-6-^<131>I was predominant. Autoradiochromatogram of faeces extract indicated the presence of a radioactive spot with an Rf value slightly lower than that of NCL-6-^<131>I. Effects of N-(4-hydroxyphenyl) salicylamide and ursodeoxycholic acid on rat biodistribution of NCL-6-^<131>I were also examined. No significant effect on the adrenal uptake and adrenal-liver ratio of NCL-6-^<131>I was observed in either case.
社団法人日本薬学会の論文
1983-06-25