Metabolic Pathway of 2-Deoxy-2-fluoro-D-glucose and 2-Deoxy-2-fluoro-D-mannose in Mice Bearing Sarcoma 180 Studied by Fluorin-19 Nuclear Magnetic Resonance
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概要
- 論文の詳細を見る
The metabolic products of 2-deoxy-2-fluoro-D-glucose (FDG) and 2-deoxy-2-fluoro-D-mannose (FDM) in sarcoma 180 cells transplanted in mice were investigated by fluorin-19 nuclear magnetic resonance (^<19>F-NMR) spectroscopy. It became apparent that the administered FDG was converted to FDM (and/or FDM-6-phosphate) in tumor cells, and also the administered FDM was converted to FDG (and/or FDG-6-phosphate). At 9h after administration of FDM, the ratio of FDG (and/or FDG-6-phosphate) and FDM (and/or FDM-6-phosphate) reached equilibrium. On the other hand, it took more than 48h in the case of FDG administration. The equilibrium amount of FDM (and/or FDM-6-phosphate) was approximately four times as much as that of FDG (and/or FDG-6-phosphate) in both cases.
- 公益社団法人日本薬学会の論文
- 1988-03-25
著者
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小嶋 正治
Faculty Of Pharmaceutical Sciences Kyusyu University
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前原 喜彦
Cancer Center Of University Hospital Kyushu University
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金沢 洋子
Faculty of Pharmaceutical Sciences, Kyushu University
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原田平 輝志
Faculty of Pharmaceutical Sciences, Kyushu University
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遠藤 英也
Medical Institute Of Bioregulation Kyushu University
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原田平 輝志
Faculty Of Pharmaceutical Sciences Kyusyu University
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栗原 悟
Faculty of Pharmaceutical Sciences, Kyushu University
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金沢 洋子
Faculty Of Pharmaceutical Sciences Kyushu University
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小嶋 正治
Faculty Of Pharmaceutical Sciences Kyushu University
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栗原 悟
Faculty Of Pharmaceutical Sciences Kyushu University
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