Relationships between Conformation of Antigen and Specificity of Antibody in Radioimmunoassay for Steroid Hormone. III. Highly Specific Cortisol-Antibody against 6α- and 6β-Hydroxycortisol 6-Hemisuccinate-Bovine Serum Albumin Conjugates
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概要
- 論文の詳細を見る
anti-6α- and anti-6β-Hydroxycortisol 6-hemisuccinate-BSA antisera (anti-F-6α-HS and anti-F-6β-HS) were obtained by immunizing rabbits. The specificity of each antiserum was assessed by determining the cross-reactivities with 37 kinds of steroids and was compared with that of anti-cortisol 21-hemisuccinate-BSA conjugate antiserum (anti-F-21-HS). anti-F-6β-HS had higher specificity than that of anti-F-6α-HS for the steroids structurally different to cortisol in ring A. anti-F-21-HS had an obviously lower specificity than those of anti-F-6α-HS and anti-F-6β-HS for the steroids differing structurally from cortisol only in the 17-side chain.
- 公益社団法人日本薬学会の論文
- 1978-09-25
著者
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曽根 久雄
Faculty Of Pharmaceutical Sciences Kyushu University
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小嶋 正治
Faculty Of Pharmaceutical Sciences Kyushu University
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