Improved Synthesis of 2-Deoxy-2-fluoro-D-glucose Using Fluoride Ion
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概要
- 論文の詳細を見る
Methyl 3-O-benzyl-4,6-O-benzylidene-2-O-(trifluoromethanesulfonyl)-β-D-mannopyranoside (7) was examined as a substrate for the preparation of 2-deoxy-2-fluoro-D-glucose (1) by fluoride ion treatment. The triflate (7) reacted rapidly with tetraalkylammonium fluorides in acetonitrile or tetrahydrofuran to give methyl 3-O-benzyl-4,6-O-benzylidene-2-deoxy-2-fluoro-β-D-glucopyranoside (10) in 52-57% yield. Removal of the protecting groups from 10 by the use of 50% methanesulfonic acid afforded the required 1 in good yield. This synthetic sequence may provide an effective alternative to known methods for preparing ^<18>F-labeled 1.
- 社団法人日本薬学会の論文
- 1985-01-25
著者
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前田 稔
九州大学大学院薬学研究院
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小嶋 正治
Faculty Of Pharmaceutical Sciences Kyusyu University
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前田 稔
Faculty of Pharmaceutical Sciences, Kyusyu University
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原田平 輝志
放射線医学総合研究所 脳イメージングプロジェクト
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前田 稔
九州大学薬学部放射性薬品化学
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原田平 輝志
Faculty of Pharmaceutical Sciences, Kyushu University
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甲斐 康信
Faculty of Pharmaceutical Sciences, Kyushu University
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尾前 裕子
Faculty of Pharmaceutical Sciences, Kyushu University
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原田平 輝志
Faculty Of Pharmaceutical Sciences Kyusyu University
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小嶋 正治
Faculty Of Pharmaceutical Sciences Kyushu University
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尾前 裕子
Faculty Of Pharmaceutical Sciences Kyushu University
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甲斐 康信
Faculty Of Pharmaceutical Sciences Kyushu University
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前田 稔
Faculty Of Pharmaceutical Sciences Kyushu University
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