コンドロイチン硫酸と陽イオン界面活性剤の混合溶液の粘度および濁度

概要

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Viscosity and turbidity of a mixed solution of chondroitinsulfuric acid and cationic surfaceactive agent were examined. Addition of a univalent cationic surfactant increases turbidity but there is no change in the intrinsic viscosity of the aqueous solution of chondrointinsulfuric acid. This is an interesting phenomenon in contrast to the lowering of intrinsic viscosity of the aqueous solution of chondroitinsulfuric acid by the addition of inorganic multivalent cation. Even in the case of cationic surfactants, extremely low ionic strength resulted in the decrease of viscosity. Binding ratio was calculated from the maximum value of turbidity of a mixed solution of chondroitinsulfuric acid and cationic surfactant. It was thereby found that the binding ratio was dependent on the concentration of chondroitinsulfuric acid present, and the number of molecules binding at the time of 1 mmole/1 of chondroitinsulfuric acid was 2.7 moles of dodecylamine hydrochloride and 5.0 moles of trimethyldodecylammonium chloride. This fact shows that, even if the length of the main hydrocarbon chain is the same, ratio of binding with chondroitinsulfuric acid becomes greater when the total number of carbon atoms is larger.
公益社団法人日本薬学会の論文
1968-06-25