安定イオウイリドの研究(第6報)Dimethylsulfonium AcetylmethoxycarbonylmethylideおよびDimethylsulfonium DiacetylmethylideとIsoquinoline 2-Oxideとの反応

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概要

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• The reaction of dimethylsulfonium acetylmethoxycarbonylmethylide (Ia) with isoquinoline 2-oxide (II) in the presence of benzoyl chloride gave 2-hydroxy-1-(1-isoquinolyl)-3-methoxycarbonylpyrrolo [2,1-a] isoquinoline (III). Dimethylsulfonium diacetyl-and acetyl-benzoylmethylides (Ib and Ic) gave 4-methyl-and phenyl-3-methylthio-2-oxo-2H-pyrido [2,1-a] isoquinolines (VII and X). Compounds VII and X were desulfurized by treatment with Raney nickel to the corresponding 4-methyl-and 4-phenyl-2-oxo-2H-pyrido [2,1-a] isoquinolines (VIII and XI). When excess Raney nickel was used, 4-methyl- and 4-phenyl-6,7-dihydro-2-oxo-2H-pyrido [2,1-a] isoquinolines (IX and XII) were obtained.

• 公益社団法人日本薬学会の論文
• 1978-02-25

著者

• 木下 敏夫

  School of Pharmaceutical Sciences, Nagasaki University

• 渡辺 三明

  Center For Instrumental Analysis Nagasaki University

• 木下 敏夫

  長崎大学薬学部

• 木下 敏夫

  School Of Pharmaceutical Sciences Nagasaki University

• 古川 淳

  長崎大学薬学部

• 青野 眞

  長崎大学薬学部

• 渡辺 三明

  長崎大学薬学部

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