Pyrimidine Derivatives. X. Synthesis of New Tricyclic Hetero Compounds Possessing a Pyrimidine Ring : 8,1,3,10-Thiatriazatricyclo[4.3.0.0^<6,10>]-dodecanes and 8,1,3,10-Thiatriazatricyclo[4.4.0.0^<6,10>]tridecanes

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概要

• 論文の詳細を見る

• Several new tricyclic hetero compounds possessing a pyrimidine ring were formed by reaction of 5-bromo- (and 5-nitro)-1-(2-bromoethyl, 3-bromopropyl, and 2-bromopropyl)-6-bromomethyl-3-methyl-2,4(1H, 3H)-pyrimidinediones (1a-c and 7a, b) with thiourea derivatives : namely, 5-bromo-(and-5-nitro)-9-imino-3-methyl-(and 3,11-dimethyl)-2,4-dioxo-8,1,3,10-thiatriazatricyclo[4.3.0.0^<6,10>]dodecanes (2a-4a, 2c, and 8a-10a) and 5-bromo-(and 5-nitro)-9-imino-3-methyl-2,4-dioxo-8,1,3,10-thiatriazatricyclo[4.4.0.0^<6,10>]tridecanes (2b-4b and 8b-10b). A new ring transformation reaction was found : compound 8b was converted to 7-acetylimino-3-methyl-2,4-dioxo-6,1,3,8-thiatriazatricyclo-[4.4.0.1^<5,8>]dodec-5(12)-ene (11) by reaction with acetic anhydride.

• 社団法人日本薬学会の論文
• 1993-09-15

著者

• 古川 淳

  School Of Pharmaceutical Sciences Nagasaki University

• 渡辺 幸弘

  School Of Pharmaceutical Sciences Nagasaki University

• 木下 敏夫

  School of Pharmaceutical Sciences, Nagasaki University

• 高石 ゆみ子

  School of Pharmaceutical Sciences, Nagasaki University

• 奥中 智子

  School of Pharmaceutical Sciences, Nagasaki University

• 中尾 世津子

  School of Pharmaceutical Sciences, Nagasaki University

• 高石 ゆみ子

  School Of Pharmaceutical Sciences Nagasaki University

• 木下 敏夫

  School Of Pharmaceutical Sciences Nagasaki University

• 奥中 智子

  School Of Pharmaceutical Sciences Nagasaki University

• 中尾 世津子

  School Of Pharmaceutical Sciences Nagasaki University

関連論文

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• An Efficient Synthesis of Phthalides by Diels-Alder Reaction of Sulfur-Substituted Furanones with Silyloxydienes : A Formal Synthesis of Mycophenolic Acid
• An Efficient Synthesis of 2(5H)-Furanone and Furan Derivatives Using 3-(Phenylthio)propenal as a 1,3-Dipolar Synthon
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