LITHIATION OF ORTHO-TOLYL TETRAMETHYLPHOSPHORODIAMIDATES : A FACILE SYNTHESIS OF 2-ARYLBENZOFURANS INCLUDING NEOLIGNAN, CARINATIN
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概要
- 論文の詳細を見る
ortho-Tolyl tetramethylphosphorodiamidates were lithiated with sec-BuLi at -105℃ to give corresponding benzylic lithio species which underwent reaction with electrophiles. When benzoates were used as electrophiles, deoxybenzoin derivatives were obtained. Acidic treatment of these products in refluxing formic acid gave 2-arylbenzofurans. The neolignan, carinatin, was successfully synthesized using this methodology.
- 公益社団法人日本薬学会の論文
- 1989-10-25
著者
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古川 淳
Faculty of Pharmaceutical Sciences, Nagasaki University
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古川 淳
School Of Pharmaceutical Sciences Nagasaki University
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川西 健司
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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渡辺 三明
Center For Instrumental Analysis Nagasaki University
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伊達 睦廣
Faculty of Pharmaceutical Sciences Nagasaki University
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堀 貴子
Faculty of Pharmaceutical Sciences Nagasaki University
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川西 健司
Faculty Of Pharmaceutical Sciences Nagasaki University
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