A Facile Synthesis of Benzo[b]furan Derivatives Including Naturally Occurring Neolignans via Regioselective Lithiation of ortho-Cresols Using the Bis(dimethylamino)phosphoryl Group as a Directing Group
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概要
- 論文の詳細を見る
A facile synthesis of 2-arylbenzo[b]furans via directed lithiation of ortho-tolyl tetramethylphosphorodiamidates as the key step is described. Lithiation of ortho-tolyl tetramethylphosphorodiamidates at -105℃ followed by reaction with aromatic esters and then acidic treatment led to 2-arylbenzo[b]furans in modest overall yields. The utility of this strategy has been demonstrated in regioselective and short syntheses of the naturally occurring neolignans carinatin, eupomatenoid-1,and eupomatenoid-13.
- 公益社団法人日本薬学会の論文
- 1991-01-25
著者
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古川 淳
Faculty of Pharmaceutical Sciences, Nagasaki University
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古川 淳
School Of Pharmaceutical Sciences Nagasaki University
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川西 健司
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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渡辺 三明
Center For Instrumental Analysis Nagasaki University
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伊達 睦廣
Faculty of Pharmaceutical Sciences Nagasaki University
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堀 貴子
Faculty of Pharmaceutical Sciences Nagasaki University
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川西 健司
Faculty Of Pharmaceutical Sciences Nagasaki University
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