Reaction of Lithiated Senecioamide and Related Compounds with Benzynes : Efficient Syntheses of Naphthols and Naphthoquinones
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概要
- 論文の詳細を見る
The reaction of lithated N, N-diethylsenecioamide and N, N-diethy-3-phenlisocrotonamide with methoxy-substituted benzynes, generated in situ from methoxy-substituted halobenzenes, gave regiospecifically various 3-methyl- and 3-phenyl-naphthol derivatives in a one-pot process. Methoxy-substituted 3-methyl-1-naphthols thus obtained were easily converted into various 1,4-naphthoquinones and 1,2-naphthoquinones including biologically active natural products such as plumbagin, plumbagin methylether, 5,6-dimethoxy-2-methyl-1,4-naphthoquinone, and 8-methoxy-3-mathyl-1,2-naphthoquinone.
- 公益社団法人日本薬学会の論文
- 1986-07-25
著者
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古川 淳
Faculty of Pharmaceutical Sciences, Nagasaki University
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渡辺 三明
Faculty of Pharmaceutical Sciences
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渡辺 三明
Center For Instrumental Analysis Nagasaki University
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久松 貞義
Faculty Of Pharmaceutical Sciences Nagasaki University
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佛坂 浩
Faculty of Pharmaceutical Sciences, Nagasaki University
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佛坂 浩
Faculty Of Pharmaceutical Sciences Nagasaki University
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