A Short and Convergent Synthesis of the Phytoalexins Vignafuran, 6-Demethylvigafuran, and Moracin M via Directed Lithiation Reaction
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概要
- 論文の詳細を見る
2-Methyl-5-(tert-butyldimethylsilyloxy)phenyl N, N, N', N'-tetramethylphosphorodiamidate was lithiated with sec-BuLi in the presence of N, N, N', N'-tetramethylethylenediamine at -105℃ to generate the corresponding benzylic anion. This benzylic anion was reacted with various methyl benzoates to provide deoxybenzoin derivatives which, without purification, were treated with formic acid to give 2-aryl-6-hydroxybenzo[b]furans. The utility of this strategy has been demonstrated by its application to the short synthesis of phytoalexins, such as vignafuran, 6-demethylvignafuran, and moracin M.
- 公益社団法人日本薬学会の論文
- 1991-03-25
著者
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古川 淳
Faculty of Pharmaceutical Sciences, Nagasaki University
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古川 淳
School Of Pharmaceutical Sciences Nagasaki University
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川西 健司
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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渡辺 三明
Center For Instrumental Analysis Nagasaki University
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川西 健司
Faculty Of Pharmaceutical Sciences Nagasaki University
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