Pyridazine誘導体の合成研究(第8報) : Alkoxypyridazine N-Oxide類のエーテル交換反応について
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概要
- 論文の詳細を見る
Ether-exchange reactions using sodium methoxide or ethoxide were examined with 3-methoxy-(IXa), 3-methoxy-4-methyl-(IXb), 3-methoxy-6-chloro-(Va), 3-methoxy-4-methyl-6-chloro-(Vb), 3-ethoxy-6-chloro-(VIa), 3,6-dimethoxy- (Ia), 3,6-diethoxy- (IIa), and 3,6-diethoxy-4-methylpyridazine 1-oxide (IIb), and 4-methoxy (XIIa) and 4-ethoxypyridine 1-oxide (XIIb). Ether exchange takes place under mild conditions and, dialkoxy compounds undergo hydrolysis under drastic conditions, forming hydroxy compounds (VII or VIII). In dimethoxy compounds, 3-position is more active than the 6-position, while this is reversed in diethoxy compounds. In dialkoxy compounds, methoxyl group is more sensitive to the ether exchange reaction than the ethoxyl group. 3-Alkoxy- and 3,6-dialkoxy-pyridazine 1-oxides submit more easily to the ether exchange reaction than 3,6-dialkoxypyridazine or 4-alkoxypyridine 1-oxide.
- 公益社団法人日本薬学会の論文
- 1967-02-25
著者
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梁井 光二
Faculty Of Pharmaceutical Sciences Nagasaki University
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梁井 光二
長崎大学薬学部
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木下 敏夫
長崎大学薬学部
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梁井 光二
Faculty of Pharmaceutical Sciences, Nagasaki University
関連論文
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- Studies on the Heterocyclic Compounds. XIX. A Novel Ring Isomerization of 3-Ylideneaminoimidazo [4,5-c] pyridazines
- 複素環化合物の研究(第18報)Imidazo[1,2-c]-およびPyrimido[1,2-c]pyrimidine誘導体の合成
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- Studies on the Pyridazine Derivatives. XVI. Reaction of 3-Alkoxy-4-nitro-(and 4,6-dinitro) pyridazine 1-Oxides with Amines
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- Studies on the Synthesis of Pyridazine Derivatives. IX. Synthesis of 10H-Pyridazino (3,2-b) quinazolin-10-one and Its Derivatives. (3)
- Pyridazine誘導体の合成研究(第8報) : Alkoxypyridazine N-Oxide類のエーテル交換反応について
- 3,6-Dimethoxy-4-nitropyridazine 1-Oxideとハロゲン化アルキルとの反応
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- Studies on the Synthesis of Pyridazine Derivatives. XI. Reaction of 3,6-Dialkoxypyridazine 1-Oxide with Alkylhalides, Haloketones and Haloacid Esters, and Decomposition of Reaction Products
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